rainerann
Star
- Joined
- Mar 18, 2017
- Messages
- 4,550
I still don’t think herd immunity is possible. Apparently, it is not likely in the case of rna viruses even without tampering.
The data summarized and discussed above illustrate that innate immune evasion is a major function of respiratory and other RNA viruses (Fig. (Fig.1),1), which probably takes a significant volume of the genetic capacity of these viruses. This also implies that, given the restricted genetic space available to these viruses, the evasive functions must be pivotal for viruses to survive, otherwise they would likely not have evolved. Since each virus employs multiple different activities to suppress immune responses, and often evolved multifunctional proteins to do so, it remains difficult to acquire a complete picture of the immune evasive arsenal of a virus and how this is balanced with symptoms and disease outcome in different cell types or situations...
An important question is how exactly the viral innate immune evasive functions of respiratory viruses influence disease outcome and ultimate immune responses. It is noticeable that many of the viruses discussed here do not elicit a long-lasting immune protection after infection, and indeed rhino, corona, and RSV can re-infect individuals sometime after earlier infection, again causing symptoms (reviewed in [178, 179]), which is in sharp contrast to several other childhood-associated viral infections, where lifelong protection is achieved after generally experiencing only one episode of disease. It may well be that, besides their strong genetic variation, the innate immune evasive activities of the mentioned respiratory viruses play a role in this lack of eliciting protective immunity [180], and to possibly improve our options for effective antiviral strategies, it seems pivotal to further investigate this.
Innate Immune Evasion by Human Respiratory RNA Viruses
The impact of respiratory virus infections on the health of children and adults can be very significant. Yet, in contrast to most other childhood infections as well as other viral and bacterial diseases, prophylactic vaccines or effective antiviral treatments ...
www.ncbi.nlm.nih.gov