the cornerstone: "the nature–like technosphere is a part of the noosphere.."

[Lalas]

St. Petersburg State Electrotechnical University "LETI" named after V.I.Ulyanov (Lenin) SPbGETU "LETI"

Программа «Приоритет-2030»

СПбГЭТУ «ЛЭТИ» вошел в число 46 университетов-участников программы «Приоритет 2030», которые получат гранты по направлениям «Исследовательское лидерство» и «Территориальное и (или) отраслевое лидерство»

prioritet2030.etu.ru

MISSION AND STRATEGIC GOAL OF SPbSETU "LETI"
within the framework of the PRIORITY 2030 program

The mission of the University is to ensure the scientific and technological leadership of industries in the areas of competence relevant to the University through advanced research and development, training of the engineering elite and harmonious personal development.

The strategic goal of the University is the formation of a reference R&D (research and development) A university in which advanced research and development, as well as training of engineering personnel, are aimed at technological development and digital transformation of enterprises in specialized sectors of the economy and territories on the basis of system integration and synergetic unification of the personnel, intellectual and corporate potentials of the University, academic and industrial partners.

To learn more…
The university relies on revolutionary changes in three directions: research, markets, education.

A revolution in research on the root markets for SPbGETU "LETI", the answer to which will be the formation of key competencies and the creation of R&D laboratories in promising areas of research.

The revolution in the markets is the University's response to which will be active participation in the formation of interdisciplinary frontiers at the junction of different sectors of industry, in expanding the areas of application of accumulated knowledge and advanced approaches (including technological foresight, design thinking, system engineering), in building promising technological maps of the development of industries and companies.

The revolution in education is the answer to which SPbSETU "LETI" sees in the formation of new ways of thinking, the creation of an academic environment and services, the promotion of knowledge around the world, international openness and cooperation, the creation of conditions for attracting and developing talents.

It is planned to create a space for experiments at SPbSETU LETI: to launch and scale the best practices in research, interaction with industry and organizations of the Russian Academy of Sciences, implementation of advanced educational programs, development of technological services to support startups, including in the formats of engineering centers; work in the format of business clubs with industrial partners, for discussion current trends in science (foresight, reports); formation and support of change teams.
..."

«Подготовка кадров и планы по внедрению разработок»: проректор ЛЭТИ Виктор Тупик о реализации программы «Приоритет 2030»

За прошедший год СПбГЭТУ «ЛЭТИ» получил ряд конкретных результатов по стратегическим проектам программы развития вуза, внедрение которых планируется начать уже в 2023 году совместно с индустриальными партнерами в сфере электроники.

prioritet2030.etu.ru

"Personnel training and plans for the implementation of developments": LETI Vice-Rector Viktor Tupik on the implementation of the Priority 2030 program

Over the past year, SPbSETU "LETI" has received a number of concrete results on strategic projects of the university development program, the implementation of which is planned to begin in 2023 together with industrial partners in the field of electronics.

26.01.2023

On January 25, a press conference dedicated to the results of the first year of participation of universities of the Northern capital in the federal program of strategic academic leadership "Priority 2030" was held at the TASS regional information center in St. Petersburg. The meeting was attended by Vice-Governor of St. Petersburg Vladimir Nikolaevich Knyaginin, Vice-Rector for Scientific Work of St. Petersburg State Technical University "LETI" Viktor Anatolyevich Tupik, as well as representatives of other universities of the city who participate in the program.

Speaking at a press conference, Viktor Anatolyevich stressed that the LETI development program is focused around two important aspects: training personnel for high-tech branches of domestic industry, as well as bridging the gap between the sphere of scientific research and the real sector of the economy.

The Vice-Rector noted that the basis for solving these tasks at LETI are three interrelated strategic projects: "Nanoheterostructural electronics, photonics and radiophotonics", which is the key, "New technologies of information connectivity of objects and territories", as well as "Technologies of strong hybrid intelligence for diagnosis, prevention, treatment and rehabilitation in applied medicine".

"The key strategic project concerns the development of new types of semiconductor nanoheterostructures. This direction will allow creating more efficient components and devices for mass implementation at enterprises. Our university has a strong foundation for conducting research in this area. Let me remind you that it was started by the Nobel laureate Zhores Ivanovich Alferov, who in the past was a student and graduate of LETI, and then a professor and head of the department of our university."
Vice-Rector for Scientific Work of SPBSET "LETI" Viktor Anatolyevich Tupik

He also clarified that over the past year, LETI scientists, during the implementation of this strategic project, have worked out methods for studying and creating nanoheterostructures, on the basis of which they have developed a line of photonic integrated circuits that are promising for creating a new class of electronic component base. Libraries of technological processes and components necessary for launching the mass production of microchips, which is planned to be organized jointly with industrial partners during 2023, are currently being formed.

According to Viktor Anatolyevich, the results of the nanoheterostructure research project are the basis for the development of devices used in ultrafast and intelligent information systems capable of transmitting large amounts of information. Such equipment is currently being developed at LETI within the framework of the strategic project "New technologies of information connectivity of objects and territories".

"On the other hand, the production of such new components, the development and use of these communication systems rests on the need to process huge amounts of information. Classical artificial intelligence may not be able to cope with this task or solve it insufficiently effectively. For this purpose, as part of our third strategic project, we have developed the concept of a strong hybrid co-evolving, which will be able to develop in close conjunction with the user, based on his individual requests and characteristics. A new type of artificial intelligence will be in demand primarily in medicine and pharmaceuticals."
Vice-Rector for Scientific Work of SPBSET "LETI" Viktor Anatolyevich Tupik

In addition, now LETI is actively developing a direction that, in terms of its significance, can reach the level of a strategic project already this year, Viktor Anatolyevich added – we are talking about electrical engineering. In the course of its development, various types of power electric conversion devices are being developed, which are extremely in demand today in such branches of domestic industry as electromotion, energy and technosphere safety.

"Another major focus of our strategic program is focused on personnel policy. We understand that it is possible to solve the problem of training specialists for high-tech industries only by attracting young people to the research field. To do this, we are developing the scientific and educational infrastructure of the university and new training formats."

Vice-Rector for Scientific Work of SPBSET "LETI" Viktor Anatolyevich Tupik
Speaking about concrete steps, he noted that in 2022, eight new laboratories for electronics, materials science, device development and artificial intelligence research were created at LETI. Now they employ more than 100 young scientists. The university has also organized three acceleration programs, which have been successfully completed by more than 600 students from 10 universities in Russia."

**
"...three interrelated strategic projects: "Nanoheterostructural electronics, photonics and radiophotonics", which is the key, "New technologies of information connectivity of objects and territories", as well as "Technologies of strong hybrid intelligence for diagnosis, prevention, treatment and rehabilitation in applied medicine"."
~~

Наногетероструктурная электроника, фотоника и радиофотоника

Разработка интегральной компонентной базы на новых физических принципах с использованием новых материалов, и разработка базовых технологий ее промышленного производства

prioritet2030.etu.ru

Nanoheterostructural electronics, photonics and radiophotonics

The goal of the strategic project is to develop an integrated component base based on new physical principles using new materials, and to develop basic technologies for its industrial production, which will form a new direction in the electronics industry: nanoheterostructural photonic integrated circuits.

Objectives of the strategic project
Development of a 9xx nm laser crystal for radiophotonic integrated circuits and pumping of high-power narrowband fiber lasers for space laser communication.

Development of pulsed radiation sources and ultra-high resolution digital matrix photodetector systems for space and lidar applications.

Development of technology for the synthesis of layered structures and nanostructures using new materials that provide the required refractive index contrast (dispersion), optical losses and other characteristics necessary to create FIS and components for them, including emitters, receivers, waveguide elements, as well as other active and passive optical components.

Topology development and prototyping of hybrid and integrated photonic circuits (such as random number generators, transceiver modules, spectrum analyzers, etc.).

Expected results of the strategic project
As a result of the project, new fundamental knowledge and practical results in the field of nanoheterostructural electronics, photonics and radiophotonics will be obtained. Basic technologies for the production of microwave electronics and photonics elements, including photonic integrated circuits, will be developed, prototypes of FIS for various functional purposes, such as monochromatic signal generators, frequency grid generators, noise and random number generators, spectrum analyzers and transceiver modules, will be created and put into production at the enterprises of industrial partners."

Новые технологии информационной связанности объектов и территорий

Цель проекта - к 2030 году войти в систему разделения труда ТОП-5 кластеров (R&D + production) на мировом рынке

prioritet2030.etu.ru

New technologies of information connectivity of objects and territories

The goal of the project is to enter the labor division system of the TOP 5 clusters (R&D + production) in the global NewRadio| 6G market by 2030, in terms of creating new principles and structural components of the NET–2030 ultra-broadband high-speed communication networks, including cognitive, hybrid, adaptive reconfigurable, heterogeneous, solving the problem of mastering new frequency bands, including subTHz.

It also provides for the transfer of high-tech solutions to key segments of the infocommunication market, for which a cumulative average annual growth rate is projected together with consortium members and industrial partners.

Objectives of the strategic project
Research and development of devices for generating, receiving and transmitting signals, promising antenna solutions and methods for controlling the electromagnetic field in mm and subTHz bands for NET-2030 systems and networks.

Construction of new radio access technologies (NewRadio|6G) of NET-2030 networks based on effective signal-code constructions and improved methods of multiple access.

Search for new principles of construction and development of cognitive reconfigurable systems of heterogeneous location and navigation.

Development of hardware and software complexes of the Internet of Everything (IoE) for the ecosystem of NET-2030 networks.

Ensuring the safety and security of data transmission in NET-2030 networks, the study of electromagnetic compatibility of nodes and structural elements of megasensory networks.

Expected results of the strategic project
Scientific and technical results:
Radio access technologies in promising NET-2030 networks using signal-code structures that are effective in a complex signal-interference environment.

Technologies for the design and manufacture of new antenna systems of mm- and sub-THz bands and the use of the principles of radiohologography in relation to the transition from classical diagram formation to the formation of optimal EMF distribution on objects.

Radiophotonic systems of transmission, reception and high-speed processing of signals and time series.

Innovative results:
Creation of a smart network of partners, including SME enterprises (small and medium-sized businesses) involved in the creation and sale of high-tech products in the field of wireless technologies.

Providing the IoE infocommunication environment by building intelligent multi-band systems as a result of the integration and development of wireless technologies.

Creation of test zones of new generation networks that ensure the implementation of ultra-high-speed digital services.

Creation of a line of promising R&D products of the "Smart Radio Environment" direction – SmartField, SmartRadioArch, SmartSpectrum (including together with foreign partners – Aalto University, Keysight Technologies, Rohde &Schwarz).

Results in the field of personnel training:
Development and implementation of educational programs at all levels for advanced training in the field of radio electronics and infocommunication technologies.

Organization of youth collectives for project educational and research work by introducing R&D projects as a basic element of Master's degree educational programs.

Development and implementation of additional professional education programs in order to transform the current personnel of the industry to a new technological way, including with the involvement of resources of international manufacturers of measuring equipment Keysight Technologies, Rohde &Schwarz.

Технологии сильного гибридного интеллекта для прикладной медицины

Технологии сильного гибридного интеллекта для диагностики, профилактики, лечения и реабилитации в прикладной медицине

prioritet2030.etu.ru

Technologies of strong hybrid intelligence for applied medicine

The aim of the project is to develop the fundamentals of Strong Hybrid Intelligence (SHI) with the construction of a technological stack based on it for the intellectualization of economic sectors and its testing in the field of applied medicine.

Objectives of the strategic project
Fundamental research. Development of a mathematically based concept of strong hybrid intelligence; approaches to ensuring the interoperability (compatibility) of human and machine intelligence in solving complex problems; principles of modeling and description of cognitive functions.

Applied solutions. Development of a technological platform for building solutions based on SHI; development of frameworks for rapid prototyping, creation and implementation of products based on SHI.

Approbation and implementation. Development and implementation of a complex of software and hardware for solving problems of practical medicine.

Education. Creation of a multi-level system of training specialists for research, development and application of solutions based on SHI.

Organizational measures and development of the region. Organization of activities for the search for new concepts for the construction of SHI, prototyping products based on it and their testing at all stages of the life cycle based on the Living Lab model; creation of experimental legal regimes supporting the processes of development, testing and implementation of a full cycle of obtaining new knowledge, creating innovative breakthrough technologies, products and services based on SHI and promoting socio-economic development of regions through technology transfer in the field of applied medicine.

Expected results of the strategic project
As a result of the project, new fundamental knowledge and practical results in the field of nanoheterostructural electronics, photonics and radiophotonics will be obtained. Basic technologies for the production of microwave electronics and photonics elements, including photonic integrated circuits, will be developed, prototypes of FIS for various functional purposes, such as monochromatic signal generators, frequency grid generators, noise and random number generators, spectrum analyzers and transceiver modules, will be created and put into production at the enterprises of industrial partners.

1.Results of fundamental research
1.1.Mathematically based concept of building a strong hybrid intelligence.
1.2.The concept of interoperability (compatibility) of interacting intelligent agents based on human and machine intelligence at different levels (neural interfaces, cognitive and semantic communication).
1.3.The concept of dynamic formation of knowledge ontologies in a hybrid environment.
1.4.The concept of coevolution of the hybrid intelligence system.
1.5.Description of the principles of ensuring the safety and ethics of the use of SHI.

2.Results of development of applied solutions
2.1.Software and hardware platform for building intelligent systems based on the SHI (GI operating core).
2.2.A software framework for rapid prototyping, creation and implementation of products based on SHI.

3.Results of approbation in the field of applied medicine
3.1.A complex of software and hardware systems, including:
3.1.1.Software and hardware system to support research and development of human cognitive functions for the construction of GI, assessment of the level of its evolution and correction of the trajectory of its formation.
3.1.2.A system based on the SHI to support research, training, situational behavior analysis and certification of medical workers using a digital double of the human body.
3.1.3.A system for supporting research and training of the SHI system when assisting a doctor in outpatient and inpatient treatment with predicting outcomes, determining risks and preventing diseases based on monitoring the patient's condition.
3.1.4.Neurorehabilitation system based on neuroplasticity management, virtual reality, system model of motor control.
3.1.5.A system of predictive analytics on the health status of individuals and cohorts of the population in certain conditions caused by natural and social factors.
3.1.6.A system of remote monitoring of human health based on the model of the digital twin of the human body and the concept of federated learning.
3.1.7.A system for improving the effectiveness of the training process.

3.2.A technology stack for working with an individual digital medical history of a person based on a private cloud.
3.3.A biointerface harmonized with a person, including the possibility of compensating for the lost functions of the body and its non-pharmacological correction.
3.4.Nanocarriers of drugs for their targeted delivery to organs with a histohematic barrier.
3.5.Mobile biomedical expert diagnostic systems based on multimedia data analysis.
3.6.Express diagnostic systems based on multimodal biochips.

4.Educational outcomes
4.1.A system of continuous training in technologies for diagnosis, prevention, treatment and rehabilitation within the framework of the concept of SHI in applied medicine.
4.2.Network and modular educational programs of basic and additional education on:
- fundamental and applied aspects of the development of SHI;
- development of solutions based on the SHI, including for the tasks of applied medicine.

5.Results of organizational measures and impact on the development of the region
5.1.Distributed research ecosystem based on the Living Lab model.
5.2.Regulatory "sandbox" for working out the legal aspects of the use of SHI in medical tasks.
5.3.School of key researchers in the field of artificial intelligence.

~~
STRATEGIC PROJECTS

Новые электронные компоненты и устройства для сверхбыстрых и интеллектуальных информационных систем

Разработка интегральной компонентной базы на новых физических принципах с использованием новых материалов, и разработка базовых технологий ее промышленного производства

prioritet2030.etu.ru

New electronic components and devices for ultrafast and intelligent information systems

The goal of the strategic project is to develop a new ECB to overcome the technological barrier caused by the achievement of the maximum technological and functional parameters of traditional silicon electronics, in order to create industrially oriented ultrafast intelligent trusted systems. It is achieved through the development and use of new photonic principles of information processing, neuromorphic and neural network models of computing and new generation devices.

Objectives of the strategic project
Development of a new component base technology based on photonic integrated circuits (FIC).

Development of the basic technology of power electronics based on silicon carbide (SiC).

Development of "smart" photonic sensors and networks based on them for the construction of human-machine systems using hybrid intelligence technologies, including unmanned aircraft systems.

Design of microwave monolithic integrated circuits for applications critical in basic parameters in unmanned systems, including those with group control.

Development of ground-based monitoring, management and security points based on the concept of a wireless information environment.

Design of safe unmanned systems based on methods and technologies of neuromorphic networks and hybrid artificial intelligence.

Development and manufacture of energy-efficient electric propulsion systems using the SiC component base.

Expected results of the strategic project
A series of FIC of various functional purposes for use in quantum computing and quantum communications systems, control systems and organization of interaction of unmanned vehicles.

The technology of defect-free single crystals and SiC epitaxial layers for the production of medium-power Schottky diodes used in energy-efficient electric propulsion systems.

Manufacturing technology and design of smart sensors for various purposes for biomedical and unmanned systems.

Experimental samples of fiber-optic and integrated photonic semiconductor sensors.

Elements and devices of heterostructural solar energy to ensure the energy efficiency of unmanned objects.

A prototype of a ground-based system for detecting and tracking unmanned objects.

Software and hardware solutions to ensure the autonomy of unmanned systems, including the management of groups of UAVs.

Designs of power inverters and rectifiers based on SiC component base."

 

[Lalas]

Ученые выяснили, как влиять на свойства клеток с помощью наночастиц кремния

innoscope.ru

Scientists have found out how to influence the properties of cells using silicon nanoparticles

September 24, 2020
Researchers from Russia have obtained experimental results necessary for the integration of cells and bacteria with silicon nanoparticles at the Kurchatov synchrotron radiation source. Scientists have also shown the possibility of producing iron nanoparticles using bacterial cells. The work of scientists is published in Results in Physics:

Peculiarities of electronic structure and composition in ultrasound milled silicon nanowires

The combined X-ray absorption and emission spectroscopy approach was applied for the detailed electronic structure and composition studies of silicon …

www.sciencedirect.com

The specialists' research was devoted to the properties of silicon nanoparticles, which is the main material of micro- and nanoelectronics. Physicists have managed to reconstruct the atomic structure of silicon-based nanoscale particles, and show that, knowing their properties, it is possible to technologically control and effectively integrate them with cells.

"The most obvious application is medicine, especially such an actively developing area as theranostics — combining the diagnosis of any diseases and therapy, including targeted therapy. Silicon nanoparticles have a high biocompatibility, unlike a number of materials used today. These materials are not always qualitatively excreted from the body, and silicon, especially in small volumes characteristic of nanoparticles, can successfully perform the necessary tasks and is easily removed after dissolution," said Sergey Turishchev, project manager, associate professor of the Faculty of Physics at Voronezh State University.

The second area of research is the combination of inorganic iron nanoparticles with E.coli bacteria cells. Iron nanoparticles themselves are formed in the cell due to certain types of protein molecules. These molecules in the cell accumulate within themselves this inorganic nanoparticle of iron oxides. The dimensions of each nanoparticle are very small, only five to six nanometers. It turns out that the molecule is actually an installation, a natural "generator" of nanoparticles. And the cage itself is a "factory". The smaller the particle size, the more difficult it is to get them unified in size and composition, but protein molecules themselves form identical particles.

A significant part of the work is devoted to theoretical modeling. Scientists have carried out precise calculations of such fundamental properties of materials underlying nanoparticles, such as, for example, the electron-energy spectrum. The simulation results are further consistent with the experiment. This allows you to get the most complete picture of complex research.

Создан опытный образец печатающей головки для российского "геномного принтера"

Это самая сложная часть оборудования, которую в России до этого никто не изготавливал, сообщил завлабораторией аддитивных технологий и инженерной биологии ТУСУР

nauka.tass.ru

A prototype printhead for the Russian "genomic printer" has been created
This is the most complex piece of equipment that no one has manufactured in Russia before, said the head of the laboratory of additive Technologies and engineering biology TUSUR

TOMSK, June 29, 2023. Scientists of Tomsk State University of Control Systems and Radioelectronics (TUSUR) have developed a printhead for a "genomic printer" - a piezoelectric dispenser. Testing of prototypes will begin in the near future, the press service of the university told TASS on Thursday.

Earlier, Ruslan Gadirov, head of the laboratory of additive technologies and engineering biology, told TASS that the so-called piezoelectric dispensers are the most difficult part of the "genomic printer", which no one has manufactured in Russia before. Prior to their development, the working layout of the printer was tested on other dispensers. The finished system will have 16 dispensers, each of which forms a droplet with a volume of about 500 picoliters (in diameter slightly larger than the thickness of a human hair).

"Within the framework of the genomic printer development project, TUSUR scientists together with JSC NPF Mikran are working on the creation of the main unit of the device - a piezoelectric dispenser designed for precision dosing of liquid materials with a drop volume of 100 picoliters. <...> To date, prototypes of a piezoelectric dispenser have been obtained and an experiment on full-fledged solid-state synthesis of oligonucleotides will be conducted in the near future," the report says.

The scientists explained that the piezoelectric dispenser forms drops of printed material with a certain frequency. Special equipment remotely monitors parameters such as the volume and shape of droplets, the speed of their passage, as well as the straightness of the trajectory and the presence of satellites.

"Improving the manufacturing technology of domestic printing heads, ensuring their multi-channel capability will ensure technological sovereignty in the field of solid-phase synthesis technologies, additive (printed) electronics and other related areas," the words of Ivan Kulinich, a researcher at the Nanotechnology Research Center, TUSUR, are quoted in the message.

About the "genomic printer"
To date, there are not so many manufacturers of equipment in the world for the synthesis of short fragments of DNA or RNA, from which it is possible to create gene constructs in the future. Most of these manufacturers are located in the USA. The policy of these companies does not allow them to freely supply equipment to third countries, as well as DNA chips necessary for the subsequent assembly of gene designs.

TUSUR won a grant from the Ministry of Education and Science in the amount of 320 million rubles for the creation of a "genomic printer" and acts as the lead performer in the project. Also, two more Tomsk universities (SibSMU and TSU), the national research center "Kurchatov Institute", the Institute of Chemical Biology and Fundamental Medicine SB RAS, the industrial partner of TUSUR - JSC "NPF"Mikran" are taking part in the work on the project."

Ученые ТУСУРа завершили работу над опытным образцом печатающей головки для геномного принтера

В Томском госуниверситете систем управления и радиоэлектроники разработан макет пьезоэлектрического дозатора, который предназначен для подачи жидких компонентов при твердофазном синтезе олигонуклеотидов.

tusur.ru

...
According to scientists, to date, prototypes of a piezoelectric dispenser have been obtained and an experiment on full-fledged solid-state synthesis of oligonucleotides will be conducted in the near future."

Новый набор плазмид упростит генетическую модификацию метилотрофных дрожжей

innoscope.ru

A new set of plasmids will simplify the genetic modification of methylotrophic yeast

June 22, 2023
The staff of the Institute of Biotechnology of the Russian Academy of Sciences (Moscow) together with colleagues from the Kurchatov Institute (Moscow) have proposed an approach that will greatly simplify the process of genome editing using the CRISPR-Cas9 system in methylotrophic yeast. As a basis, the authors took two artificial plasmids — circular DNA molecules — one of which carried a gene encoding the Cas9 protein, and the second — a short RNA that recognizes a place in the genome that needs to be "edited". In addition, bacterial genes providing resistance to the antibiotic geneticin were included in the sequence. These genes served as a kind of marker, with the help of which it was possible to accurately identify those yeast cells in which plasmid insertion was successful. So, if the yeast was able to grow on an antibiotic medium, it means that the CRISPR-Cas9 system was also present in them.

The researchers simultaneously injected the two plasmids described above into yeast cells, having previously cut them in a special way so that they could "find" each other in the cell and connect the end sections in a single sequence. The resulting single plasmid was maintained in yeast cells autonomously, that is, without insertion into the chromosome. After the CRISPR-Cas9 system delivered in this way performed its gene editing function, the plasmid was removed. The authors demonstrated the effectiveness of the proposed approach by successfully editing the genomes of four species of methylotrophic yeast: Ogataea polymorpha, O. parapolymorpha, O. haglerorum and Komagataella phaffii.

"Potentially, our system can be used to change several genes at the same time, but we have yet to test this in new experiments. At the same time, we already have a good tool for editing the genomes of methylotrophic yeast, which expands the possibilities of using them to create recombinant protein producing strains and apply metabolic engineering methods to them," says one of the authors of the study, Mikhail Agafonov, PhD, head of the group of genetic engineering of lower eukaryotes FITZ of Biotechnology of the Russian Academy of Sciences."

Технология CRISPR вошла в программу фундаментальных научных исследований до 2030 года

Премьер-министр РФ Михаил Мишустин утвердил Программу фундаментальных научных исследований на 2021–2030 годы с объемом финансирования более 2,1 трлн рублей. Среди медицинских направлений превалируют генетические технологии, в том числе упоминается метод редактирования генома CRISPR/Cas9. Его...

vademec.ru

CRISPR technology has been included in the program of fundamental scientific research until 2030

January 10, 2021
The Prime Minister of the Russian Federation Mikhail Mishustin approved the Program of fundamental scientific research for 2021-2030 with a funding volume of more than 2.1 trillion rubles. Genetic technologies prevail among medical areas, including the CRISPR/Cas9 genome editing method. It is planned to use it for the treatment of neuroblastoma.

Among the sources of financing for the project are two other state programs – "Scientific and technological development of Russia" and "Development of healthcare". "The program is focused on the development of all areas of fundamental scientific knowledge, including such areas as computer science, nanotechnology, clinical and preventive medicine," the government's website says.

Considerable attention in the program is paid to scientific tasks and "expected breakthrough results" in oncology. Based on CRISPR/Cas9 technology, for example, it is planned to create viral and non-viral genetic constructs "for knockout of urokinase and urokinase receptor genes in tumor cells, in particular neuroblastoma."

The method is based on the "cutting" of DNA – Cas9-nuclease allows you to separate both DNA strands in a certain place. Then the ends of this "incision" are connected by homological repair using the material of the second chromosome in such a way as to exclude the defect that caused the disease. In 2020, scientists Emmanuel Charpentier and Jennifer Doudna, who discovered CRISPR/Cas9, received the Nobel Prize in Chemistry.

Promising tasks include, according to the program, the development and creation of diagnostic tests based on the identification and analysis of circulating tumor cells and tumor DNA in peripheral blood, in other words, liquid biopsy. It is also planned to work on molecular profiling of tumors, including the discovery of new molecular determinants-driver genes and markers of metastasis, as well as to study the role of stem cells and signaling pathways that control metastatic colonization by tumor cells, disorders in which determine the progression of the tumor.

The urgency of studying the mechanisms of development of drug resistance of tumors for the subsequent development of innovative drugs is emphasized. "One of the promising areas of modern fundamental oncology is immuno-oncology, which studies the mechanisms of tumor "care" from immunological "supervision", immunological checkpoints. The result of such studies should be the development of a new generation of antitumor vaccines – T-cell, neoantigenic vaccines," the program says.

It is also planned to search for promising targets for antitumor therapy, develop personalized treatment methods, including using nuclear medicine methods, effective methods of drug delivery to tumors, identify genetic mutations – markers of predisposition to cancer, followed by the creation of a database of mutations in the population associated with the risk of cancer, and a registry of "patients". – carriers of mutations in Russia.

The program also outlines plans for the development of vaccines, including a new generation (genetic engineering technologies, methods of reverse genetics and nanotechnology), against tuberculosis, HIV, hepatitis B and C, influenza, developments in the field of transplantology, including bioengineering (the creation of biomedical cellular and tissue-engineered liver and cartilage products) and many other directions.

Source: Government of the Russian Federation"

 

[Lalas]

CRISPR technology has been included in the program of fundamental scientific research until 2030

January 10, 2021
The Prime Minister of the Russian Federation Mikhail Mishustin approved the Program of fundamental scientific research for 2021-2030 with a funding volume of more than 2.1 trillion rubles. Genetic technologies prevail among medical areas, including the CRISPR/Cas9 genome editing method. It is planned to use it for the treatment of neuroblastoma.

Among the sources of financing for the project are two other state programs – "Scientific and technological development of Russia" and "Development of healthcare". "The program is focused on the development of all areas of fundamental scientific knowledge, including such areas as computer science, nanotechnology, clinical and preventive medicine," the government's website says.

Considerable attention in the program is paid to scientific tasks and "expected breakthrough results" in oncology. Based on CRISPR/Cas9 technology, for example, it is planned to create viral and non-viral genetic constructs "for knockout of urokinase and urokinase receptor genes in tumor cells, in particular neuroblastoma."

The method is based on the "cutting" of DNA – Cas9-nuclease allows you to separate both DNA strands in a certain place. Then the ends of this "incision" are connected by homological repair using the material of the second chromosome in such a way as to exclude the defect that caused the disease. In 2020, scientists Emmanuel Charpentier and Jennifer Doudna, who discovered CRISPR/Cas9, received the Nobel Prize in Chemistry.

Promising tasks include, according to the program, the development and creation of diagnostic tests based on the identification and analysis of circulating tumor cells and tumor DNA in peripheral blood, in other words, liquid biopsy. It is also planned to work on molecular profiling of tumors, including the discovery of new molecular determinants-driver genes and markers of metastasis, as well as to study the role of stem cells and signaling pathways that control metastatic colonization by tumor cells, disorders in which determine the progression of the tumor.

The urgency of studying the mechanisms of development of drug resistance of tumors for the subsequent development of innovative drugs is emphasized. "One of the promising areas of modern fundamental oncology is immuno-oncology, which studies the mechanisms of tumor "care" from immunological "supervision", immunological checkpoints. The result of such studies should be the development of a new generation of antitumor vaccines – T-cell, neoantigenic vaccines," the program says.

It is also planned to search for promising targets for antitumor therapy, develop personalized treatment methods, including using nuclear medicine methods, effective methods of drug delivery to tumors, identify genetic mutations – markers of predisposition to cancer, followed by the creation of a database of mutations in the population associated with the risk of cancer, and a registry of "patients". – carriers of mutations in Russia.

The program also outlines plans for the development of vaccines, including a new generation (genetic engineering technologies, methods of reverse genetics and nanotechnology), against tuberculosis, HIV, hepatitis B and C, influenza, developments in the field of transplantology, including bioengineering (the creation of biomedical cellular and tissue-engineered liver and cartilage products) and many other directions.

Source: Government of the Russian Federation"

Source: Government of the Russian Federation"

Михаил Мишустин утвердил программу фундаментальных научных исследований до 2030 года

Распоряжение от 31 декабря 2020 года №3684-р

government.ru

Mikhail Mishustin approved the program of fundamental scientific research until 2030

January 9, 2021 11:00

Order No. 3684-r dated December 31, 2020

The development of the intellectual potential of Russian science, the creation of an effective management system for scientific research to increase their importance and relevance for the economy – these are the main objectives of the new ten-year program. It was approved by the order of the Prime Minister Mikhail Mishustin.

The program of fundamental scientific research was developed by the Russian Academy of Sciences with the participation of ministries and leading scientific organizations of the country. The document consists of several subroutines. Among them are "Analytical and predictive research aimed at identifying major challenges and improving the strategic planning system, ensuring the competitiveness and scientific leadership of Russia", "Fundamental and exploratory scientific research conducted at large scientific installations and facilities of the Megasience class".

The program is focused on the development of all areas of fundamental scientific knowledge, including such areas as computer science, nanotechnology, clinical and preventive medicine.

The new program will be funded, among other things, through the state programs "Scientific and Technological development of Russia" and "Development of Healthcare". The total amount of financing until 2030 is more than 2.1 trillion rubles.

Order No. 3684-r dated December 31, 2020, the government PDF
As a text from library for normative documents:

Распоряжение Правительства РФ от 31.12.2020 № 3684-р

Распоряжение Правительства Российской Федерации от 31.12.2020 № 3684-р "О Программе фундаментальных научных исследований в Российской Федерации на долгосрочный период (2021 - 2030 годы)"

npalib.ru

Decree of the Government of the Russian Federation No. 3684-r dated 31.12.2020 "On the Program of Fundamental Scientific Research in the Russian Federation for the Long-term period (2021-2030)"

dated December 31, 2020 No. 3684-r
(As amended by the Decree of the Government of the Russian Federation No. 966-r dated 21.04.2022)

I. General provisions

The Program of Fundamental scientific research in the Russian Federation for the long-term period (2021-2030) (hereinafter referred to as the Program) was developed in accordance with the Federal Law "On the Russian Academy of Sciences, Reorganization of State Academies of Sciences and Amendments to Certain Legislative Acts of the Russian Federation".

The program takes into account the provisions of the following regulatory legal acts:

Federal Law "On Science and State Scientific and Technical Policy";

Federal Law "On Lomonosov Moscow State University and St. Petersburg State University";

Federal Law "On the National Research Center "Kurchatov Institute";

Federal Law "On the Russian Scientific Foundation and Amendments to Certain Legislative Acts of the Russian Federation";

Decree of the President of the Russian Federation No. 899 dated July 7, 2011 "On Approval of Priority Directions for the Development of Science, Technology and Technology in the Russian Federation and the List of Critical Technologies of the Russian Federation";

Decree of the President of the Russian Federation No. 683 of December 31, 2015 "On the National Security Strategy of the Russian Federation";

Decree of the President of the Russian Federation No. 642 dated December 1, 2016 "On the Strategy of Scientific and Technological Development of the Russian Federation";

Decree of the President of the Russian Federation No. 91 dated February 23, 2017 "On Approval of the Fundamentals of State Policy in the Field of Development of the Military-Industrial complex of the Russian Federation for the period up to 2025 and beyond";

Decree of the President of the Russian Federation No. 490 dated October 10, 2019 "On the Development of Artificial Intelligence in the Russian Federation";

Decree of the President of the Russian Federation No. 20 of January 21, 2020 "On Approval of the Food Security Doctrine of the Russian Federation";

Resolution of the Government of the Russian Federation No. 1781 of December 30, 2018 "On the Implementation by the Federal State Budgetary Institution "Russian Academy of Sciences" of Scientific and Methodological Guidance of Scientific and Scientific and Technical Activities of Scientific Organizations and Educational Institutions of Higher Education, as well as the Examination of scientific and Scientific and Technical results obtained by these organizations, and on the introduction of amendments to some acts of the Government of the Russian Federation".

These documents define the normative legal basis for the creation of an integrated effective system for the organization of fundamental and exploratory scientific research in the Russian Federation, which is the most important condition for achieving the goals and objectives of the Program.

Fundamental science as a system-forming institution of long-term development provides the state with the recognition of emerging major challenges and the formation of scientific and technological results necessary for a timely response to such challenges, including through the implementation of the Program.
...
The program is aimed at obtaining new knowledge about the laws of the development of nature, society, and man, contributing to sustainable scientific, technological, socio-economic and cultural development, strengthening the national security of the Russian Federation.

The program is an instrument of state support for fundamental and exploratory scientific research aimed at solving significant scientific problems, including in priority areas established by strategic planning documents and determining the socio-economic, scientific and technological development of the Russian Federation.
.....

II. Priorities and objectives of the state policy in the field of Program implementation

The implementation of the Program ensures the coordination and implementation of fundamental and exploratory scientific research, taking into account the fundamental directions, principles and priorities of state policy established by strategic planning documents defining the socio-economic and scientific and technological development of the Russian Federation.

Taking into account the priorities and goals of the state policy in the field of socio-economic and scientific-technological development of the Russian Federation, the purpose of the Program is to gain new knowledge about the basic laws of the structure, functioning and development of man, society, nature, necessary for sustainable scientific-technological, socio-economic and cultural development of Russia, strengthening its national security and ensuring scientific leadership of the country in determining the world scientific agenda for the long term.
.....

____________
APPENDIX No. 1
to the Program of Fundamental
Scientific Research in the Russian Federation for a long-term period
(2021 - 2030)

THE PLAN
of fundamental and exploratory scientific research
for 2021 - 2030

(As amended by the Decree of the Government of the Russian Federation No. 966-r dated 21.04.2022)


I. Field of scientific knowledge: 1. Natural sciences

Direction of science: 1.1. Mathematical sciences

Main scientific tasks and expected breakthrough results for 2021 - 2030

The main scientific tasks of the development of mathematical sciences, the solution of which will open up fundamentally new opportunities for obtaining the expected breakthrough scientific results, include the following.

In the field of mathematical logic, set theory, model theory, algorithm theory (including one of the seven problems of the third millennium) and computational complexity, as well as proof theory are distinguished. A new direction is relevant - homotopy type theory and structural proof theory, closely related to computability theory and functional programming languages, which will find application in biology and physics, including quantum computing and DNA computing. A promising application of logic to computer science is modal logic.
....
The fundamental direction is the dynamics of classical and quantum complex systems. The central problems in this area are related to the construction and investigation of solutions of Newton's or Schrodinger's equations for a system of many particles, the development of the theory of geometric quantization of classical phase manifolds and dynamical systems, the study of the properties of quantum field models, as well as the problems of the theory of gravity. A promising direction is the development of mathematical methods focused on the creation of quantum technologies. Mathematical methods of quantum technologies are of high theoretical and applied interest. An important direction is the development of the Yang-Mills theory.

The actual scientific tasks of computational mathematics are inverse and incorrectly posed problems, the development of tensor and sparse approximation methods, statistical modeling and data analysis methods, optimization and control methods, numerical methods and hybrid technologies for a wide range of mathematical modeling problems where it is necessary to solve differential, integral, functional and other equations. New tasks and the development of this direction include the use of algorithms on high-performance computing systems, the introduction of modern methods of data analysis, machine learning and artificial intelligence methods.

The modeling of complex phenomena and processes in physics, chemistry, biology (including elementary particle physics, plasma physics, quantum chemistry, direct calculation of turbulent flows, gorenje processes, molecular dynamics) is promising in the development of mathematical modeling. The use of mathematical modeling is relevant in medicine and agriculture, in the study of economic and social processes, tasks of state and corporate governance, the development of new industrial technologies, in the aerospace industry, energy (including nuclear, as well as in the extraction and exploration of natural resources), robotics. The overactual tasks of mathematical modeling include the study of the habitat, including the regions of the Far North, the modeling of the atmosphere and ocean, and the study of climate.

The use of high-performance computing will have a great impact on the development of fundamental sciences (physics, chemistry, biology, medicine, etc.), the aerospace industry, energy, industry and many other fields of activity.
...
The most important tasks of theoretical computer science and discrete mathematics are research in the field of artificial intelligence, as well as the creation and implementation of new methods and algorithms for processing and analyzing big data. Promising areas include the analysis of time series, signals, images and video data, as well as texts and character sequences. Research in the field of discrete analysis, combinatorics, graph theory, discrete optimization, coding complexity theory, compression, protection and information transmission remain relevant.

The world-class tasks in the field of system programming are the creation and development of methods and appropriate technologies for the development, maintenance and analysis of programs and information and communication systems, as well as the improvement of existing and the creation of new types of system and infrastructure software. Emerging new types of applications (cloud environments, artificial intelligence, the Internet of Things, etc.), a significant complication of hardware impose increasing requirements on system software.

In the coming decades, in connection with the transition to the digital economy, tasks are being set in the field of information and computing systems and environments. It is necessary to develop mathematical methods for effective management of distributed computing environments based on distributed registry technologies (blockchain and smart contracts).

List of priority areas of fundamental and exploratory scientific research for 2021-2030
...
1.1.5. Artificial Intelligence
..
1.1.5.5. Cognitive systems and technologies, neuroinformatics and bioinformatics, system analysis

1.1.5.6. Quantum deep machine learning based on quantum search algorithms, quantum programming, quantum neural networks and quantum genetic algorithms
...
1.1.7. System programming

1.1.7.8. New generation networks (including cognitive, hybrid, heterogeneous) for transmitting exabyte volumes

***
Direction of science: 1.2. Computer and Information Sciences

Main scientific tasks and expected breakthrough results for 2021 - 2030

The main scientific tasks in the field of computer and information sciences include research from the creation of theoretical and methodological foundations, methods, model tools and information technologies of system analysis for the study and evaluation of the prerequisites, course and consequences of socio-economic processes to complexes of mathematical methods, algorithms and programs for detecting and neutralizing malicious code and hidden channels. Using only an empirical approach, it is impossible to create such high-tech technical means as such nuclear reactors, lasers, computers, robots. The condition for their creation is the study of physical, chemical and other phenomena and processes underlying the principle of their operation, the creation of mathematical models of these devices, the study of their interaction with humans and the development of bioinformatics.

The most important directions are the creation of artificial intelligence systems, text extraction and analysis, the development of methods and information technologies for system analysis and management in conditions of uncertainty and risk, the development of methods for searching areas with chaotic dynamics, methods of analysis, stabilization and control for families of systems described by both continuous and discrete equations.

A promising direction is the creation and development of a new analytical and computer technology for the study, analysis and management of chaotic dynamics of solutions to complex nonlinear systems of differential equations describing numerous natural-scientific and socio-economic processes and phenomena.


List of priority areas of fundamental and exploratory scientific research for 2021 - 2030

1.2.1. Computer, Information sciences and bioinformatics

1.2.1.1. Information theory, scientific foundations of information and computing systems and networks, informatization of society, quantum methods of information processing
1.2.1.2. Quantum Computer Science and Cryptography
1.2.1.3. Location systems, geoinformation technologies and systems
[and others]

***
Direction of science: 1.3. Physical Sciences

Main scientific tasks and expected breakthrough results for 2021 - 2030

In the field of astronomy and astrophysics, the fundamental tasks of the next decade are related to the origin and evolution of the Universe, the synthesis of chemical elements, the emergence and development of life in space, the nature and evolution of dark matter and dark energy, the appearance of the first objects in the Universe and the formation of chemical elements. Important tasks include the study of planetary systems around other stars of our Galaxy and the search for other forms of life.

In cooperation with international institutions, work will continue on the registration of gravitational-wave signals from merging black holes and neutron stars, including in the electromagnetic wavelength range. The Spektr-RG X-ray space Observatory will play a fundamental role in solving the problems of the evolution of the Universe. Significant progress in understanding the nature of objects with ultrahigh densities will be made by research conducted jointly with the world community in the field of neutrino astronomy and physics of ultrahigh-energy cosmic rays, using astronomical methods in conjunction with methods of nuclear physics. Russian scientists will take part in the study of the planets of the Solar System, primarily Venus and Mars. Considerable efforts will be directed to the development of technical means for studying the Moon. Russian scientists and engineers will have to solve the problems of mastering the infrared and millimeter wavelength ranges, which will allow studying the physical properties of cold matter in the Universe. To solve the most important problems of natural science, Russia will need to join the largest international organizations, such as the European Southern Observatory, the consortium of a Network of radio telescopes with an area of a square kilometer, the consortium for the gravitational astronomy program, the consortium of neutrino detectors and others.

The problems of astronomy and astrophysics are closely intertwined with modern problems of nuclear physics, including the search for the boundaries of our world and the determination of the possible number of chemical elements. Along with space research, the search for new types of matter will continue at the Large Hadron Collider.

Fundamental research of oscillatory and wave systems and processes used to create new systems for generating, converting and registering electromagnetic waves, as well as the use of new systems for environmental diagnostics will be continued. Such traditional fields as radiophysics, acoustics and acousto-electronics are developing. Particular attention is paid to the fundamental problems of radio wave propagation, methods and means of generating, amplifying, converting and receiving electromagnetic waves (primarily in the terahertz range), the development of coherent microwave radiation sources.

Fundamental research in the field of modern optics, photonics and laser physics, including the creation of new laser generators and the study of the interaction of laser radiation with matter, are of particular interdisciplinary interest. All over the world, the list of priority areas includes research in the field of physics of extreme light fields and the extreme state of matter, primarily on the problems of creating record-breaking powerful radiation sources with unique parameters (including X-ray and terahertz, attosecond pulses, using charged particle beams) and their applications. A technological breakthrough is expected in integrated, fiber and adaptive optics, where a special task is to miniaturize optical elements and combine them with electronic components. New photonics tools will become the basis of methods for optical diagnostics of substances with ultra-high spatial, temporal and energy resolution. The achievements of photonics stimulate the development of new scientific directions, will ensure the revolutionary development of modern materials science, electronics, energy, robotics, computer science, medicine.

The research plan includes measures to create new energy sources, including those based on controlled nuclear fusion, as well as to develop new methods for generating intense streams of accelerated particles and electromagnetic radiation. The Russian Federation has a priority in the field of creating gyrotrons - radiation sources used to heat plasma and generate direct currents that ensure the stability of controlled fusion plants. The focus of fundamental research in the field of plasma physics will remain large international projects for the development of controlled fusion energy (including the international experimental thermonuclear reactor ITER). Another area of physics of extreme states of matter is research in the field of physics of low and ultra-low temperatures, where effects such as superconductivity, superfluidity and low-temperature magnetism are manifested.

A new breakthrough direction is quantum technologies, the development of which makes it possible to search and study new effects that are interesting from the point of view of understanding quantum mechanics, and also provides the creation of fundamentally new devices, for example, with elements of nanophotonics and nanoplasmonics, with potential applications in the field of quantum informatics, cryptography, sensors, telecommunications.

Studies of the physical and technological foundations of the creation of elements of quantum simulators, quantum computers and quantum communications, including using superconducting structures, laser-cooled atoms in vacuum traps, impurity atoms in isotopically pure semiconductors, quantum dots, photonic chips, remain relevant. The high applied significance of such studies is determined by the need to develop new time and frequency standards, improve metrological and navigation systems, and create new sensory instruments.

These studies are directly related to the main tasks of condensed matter physics, the physical and technological foundations for the creation of new types of functional materials and devices with specified characteristics. Of considerable interdisciplinary interest is the creation of new types of functional materials and structures: semiconductors and nanoheterostructures (including compounds with the structure of perovskites), high-temperature superconductors, structural materials and composites, structures and coatings with specified characteristics (for example, heat-resistant, with specified tribological properties, "smart" materials, effective photovoltaic materials). In the field of condensed matter physics, the search and research of various physical effects will also continue, including such as nonlinear effects, polaritons (light-matter hybrid states), electronic effects associated with strong spin-orbit interaction, spin waves and other excitations, processes of their generation, detection, propagation, Bose condensation.

Medical physics will develop in terms of deep fundamental research at the intersection of physics, chemistry and biology and in terms of developing new methods and tools for the diagnosis and treatment of various diseases.

Within the framework of the formulated main tasks, the fundamental foundations of technologies of high applied importance will be developed, including nuclear, laser-optical (photonic), quantum, coordinate-navigation and metrological, medical, and physical materials science technologies. All this fully corresponds to the priorities of the Strategy of Scientific and Technological Development of the Russian Federation, approved by Decree of the President of the Russian Federation dated January 1, 2016 No. 642 "On the Strategy of Scientific and Technological Development of the Russian Federation" (hereinafter - the Strategy)."
~~~~
....continues

 

[Lalas]

Распоряжение Правительства РФ от 31.12.2020 № 3684-р

Распоряжение Правительства Российской Федерации от 31.12.2020 № 3684-р "О Программе фундаментальных научных исследований в Российской Федерации на долгосрочный период (2021 - 2030 годы)"

npalib.ru

...
Direction of science: 1.4. Chemical Sciences

Main scientific tasks and expected breakthrough results for 2021 - 2030

The primary task of modern fundamental research in the field of chemistry remains the search for methods for controlling chemical reactions at the level of individual reacting molecules, which is the basis of all practical applications of modern chemical knowledge from biochemical medical analysis to the development of large-scale chemical production.

Another key task of the chemistry of the future is to establish the chemical mechanisms of the appearance of life and processes in living systems. The study of the chemistry of thinking and memory of living systems, closely related to the development of artificial intelligence and the development of bionic technologies, will be of priority importance. The development of a complex of chemical and interdisciplinary approaches to the description of the complexity of living systems will ensure the transition to integrated management of life processes at the molecular level. The fundamental study of the chemical nature of living organisms is the basis for the development of medicines and methods of treatment for incurable and socially significant diseases within the direction of fundamental physico-chemical studies of the mechanisms of physiological processes and the creation on their basis of pharmacological substances and dosage forms for the treatment and prevention of socially significant diseases. The tasks of creating new drugs for the early diagnosis and treatment of oncological and severe viral diseases, autoimmune and orphan diseases will be of great importance. A big challenge for chemistry is antibiotic resistance and the search for alternative, fundamentally new antibacterial agents.

Due to global climate changes, research aimed at protecting the environment and reducing anthropogenic pressure on ecosystems will play an increasing role in the development of chemical science. Understanding the chemical relationships of the planetary complex, including the earth, the sea, the atmosphere and the biosphere, will effectively maintain the complex ecological balance and viability of the biosphere of our planet. The solution of this fundamental problem is of fundamental importance for the development of public policy aimed at preventing environmental degradation. One of the key directions of the "green chemistry" of the future is the creation of biosimilar chemical technologies using self-assembling complex systems and materials. Dynamic self-organization of mixtures of chemical components into complex systems from nanoscale to macroscopic, by analogy with biological assembly, will become the basis of a technical revolution in chemical production. The new principles of chemical transformation of substances based on the transition from the synthesis of compounds in need of isolation and purification to the "self-optimizing" targeted synthesis of the finished product will raise the efficiency of chemical production to a fundamentally new level and at the same time reduce the burden on the environment.

Socially oriented development of new materials and technologies for their production, creation of effective systems for protecting citizens from terrorism, accidents, crimes and diseases, and minimizing damage in the event of man-made disasters remain important tasks. Research in this area will be aimed at creating highly selective sensors and test systems for the identification of hazardous substances and organisms, rapid and reliable detection of toxic and dangerous chemicals, as well as explosives.

The breakthrough areas will include the development of compounds and materials with specified properties, innovative materials to provide the material basis of information technologies that determine the success of the innovative industry. The "biosimilar" strategy of chemical synthesis combined with chemoinformatics and rapid screening methods opens up the possibility of obtaining fundamentally new, adaptive, self-healing smart "device materials", "hybrid materials" combining organic and inorganic compounds, and molecular machines integrated with neural networks and machine learning systems. The development of self-assembly chemistry will result in the creation of compact, programmable, universal synthesizers of materials capable of producing functionally different materials from the same set of starting components and adapting the final product to a specific task.

One of the key areas of fundamental research in chemistry will be chemical problems of obtaining and converting energy, using alternative and renewable energy sources. In the conditions of growing competition for energy resources and the reduction of the global resource base, the development of "green" energy based on renewable cheap energy with new ways of its production, storage and transportation will be relevant. Modern methods of energy production and use, based on the consumption of finite resources and natural resources of the planet, create environmental pressure on the environment and humanity. An effective alternative to fossil fuels, along with nuclear power, will be the use of various types of fuel cells based on hydrogen, the use of inexhaustible energy from sunlight and the use of superconductors, which will significantly reduce transmission losses and increase the efficiency of energy distribution.


List of priority areas of fundamental and exploratory scientific research for 2021 - 2030

1.4.1. Fundamentals of chemistry

1.4.1.3. Approaches to the production of biologically active organic compounds
...
1.4.2. Scientific foundations for the creation of new materials with specified properties and functions, including high-purity and nanomaterials

1.4.2.2. Methods and technologies for obtaining inorganic, organic and hybrid nanomaterials and composite nanomaterials for alternative energy

...
1.4.5. Fundamental physico-chemical studies of the mechanisms of physiological processes and the creation on their basis of pharmacological substances and dosage forms for the treatment and prevention of socially significant diseases

1.4.5.1. Creation of innovative medicines and vaccines
1.4.5.2. Chemical design of molecular sensors and indicators for the diagnosis of socially significant human diseases
1.4.5.3. New methods of medical chemistry
1.4.5.4. Chemical and biological screening of new medicines
1.4.5.5. Targeted drug delivery systems
1.4.5.6. Radiopharmaceuticals for diagnostics and therapy

..
1.4.7. Chemical and physico-chemical processes and materials for information technologies

1.4.7.1. Materials with low dielectric constant for electronics and photonics devices
1.4.7.2. Materials and functional structures for optical logic devices (modulators, nonlinear optical materials, ferroelectrics, etc.) and for 3D optical memory
1.4.7.3. Computing systems based on organic and inorganic memristors

***
Direction of science: 1.5. Earth Sciences

Main scientific tasks and expected breakthrough results for 2021 - 2030

New fundamental knowledge constantly forms the basis for the development of Earth sciences and at the same time contributes to the solution of the most important tasks, including the development of the mineral resource base, the search and development of unconventional reserves of energy resources, safe and resource-saving mining, forecasting and prevention of dangerous catastrophic natural and man-made phenomena, adaptation to environmental and climate changes.
...

***
Direction of science: 1.6. Biological sciences

Main scientific tasks and expected breakthrough results for 2021 - 2030

Modern biology considers the organization of living systems on two levels. General biology studies processes at the level of organisms, populations, species, communities and ecosystems in their interaction with the environment. Physico-chemical biology studies the molecular foundations of life, the composition and structure of cells and the molecular processes underlying their vital activity.

Research in the field of biology of development and evolution of living systems is aimed at solving the most important problems of biology - understanding the evolution of living organisms, the mechanisms of formation of biological diversity and the role of ontogenetic transformations in this process. Knowledge of these mechanisms allows us to understand the course of the evolutionary process in the organic world in the past and predict its changes in the future.

Studies of the ecology of organisms and communities are aimed at obtaining new knowledge about the structure and functions of living systems at the level of organisms, populations, communities and ecosystems, to identify factors, mechanisms and patterns of their functioning and dynamics in connection with global changes on Earth (including climate change and anthropogenic impact). The analysis of these processes will make it possible to understand and assess the impact of global changes on natural biodiversity due to the oppression of native and alien species from other climatic zones and more resistant to anthropogenic influences.

Studies of biological diversity and bioresources are aimed at obtaining new results to assess their current state and dynamics. Of great importance is the study of still unexplored groups of organisms, communities and biocenoses. These works are necessary for the creation of new biological collections and the development of new biotechnologies (for agriculture, forestry and fisheries, pharmaceuticals, environmental conservation, etc.). Such studies will allow the development of new technologies for the sustainable and sustainable use of natural biological resources.

Research in the field of general genetics is aimed at elucidating the molecular genetic mechanisms of genotypic and phenotypic variability and adaptations of organisms, developing the basics of managing the gene pools of organisms. Current research will be carried out to identify genes and gene networks that control the development of valuable traits of plants and animals, to develop molecular markers for breeding, as well as to study the mechanisms of interaction "parasite - host" using omix technologies (at the genomic, transcriptomic and proteomic levels). Research on the structure of the gene pool and the history of the formation of the peoples of Russia is also relevant and extremely important.

Studies of soils as a component of the biosphere are of exceptional importance, since their fertility is the most important factor in providing food to the population of our planet. In this regard, it is of great importance to study the impact of global climate change and economic activity on the ecological functions of soils, to understand the direction and speed of elementary soil processes during the natural and anthropogenic evolution of soils due to exogenous inputs (fertilizers, herbicides, pesticides). This will allow the development of biogeochemical standards related to the impact on the environment and human health. Of particular relevance are the issues of regulation of cycles of biophilic elements in terrestrial ecosystems, including the study of the special role of soil in carbon and nitrogen cycles and the assessment of the role of soils and soil cover in greenhouse gas emissions and runoff.

Research in the field of functional microbiology includes the analysis of microbial communities of various ecological niches, the development of methods for analyzing their metagenomes, the search for producers of new antibiotics and biocatalysts. It is relevant in experimental plant biology to study the detailed mechanisms of photosynthetic processes with the prospect of creating effective artificial photosynthetic systems in the future, which will allow obtaining an inexhaustible source of food resources directly from the atmosphere. The most important tasks of this direction are the creation of a methodology for controlled plant ontogenesis and productivity; the study of strategies and mechanisms of their adaptation to environmental stress factors; the construction of biologically safe plant lines with specified properties using genetic editing.

Research in the field of biochemistry, biophysics and structural biology is aimed at identifying and establishing the composition and spatial structure of biomolecules; understanding how the structure of biomolecules determines their function. The study of the totality of chemical reactions of the cell and the laws of their catalysis will reveal new application points for the creation of new drugs and other bioregulators of cellular processes. Based on the data obtained, the design (primarily computer-based) and synthesis of biomolecules of any class and their non-natural analogues will be developed, including through organic synthesis methods, as well as protein, cellular and genetic engineering.

Molecular biology, molecular genetics and genomic research are aimed at studying the mechanisms of storage, transmission and realization of genetic information. Of particular importance are the establishment of molecular mechanisms of interaction of proteins and low-molecular bioregulators with DNA and RNA, as well as the disclosure of regulatory mechanisms of coordinated functioning of genes, leading to the appearance of certain features, and the study of post-transcriptional stages of expression of genetic information. Genome-wide studies will allow us to create new methods of diagnosis and therapy of the most common hereditary diseases. Great prospects are opening up in connection with the development of genomic editing, through which the production of modified organisms will be widely developed.

Research in the field of cell biology and immunology is aimed at elucidating the causes of oncological diseases, largely associated with disorders of cellular differentiation and immunity. In this regard, the most important tasks of this direction are the identification of genetic programs of aging, death and mechanisms of disruption of normal cell development, the development of methods to increase the effectiveness of the body's immune system. Of particular importance is the production of stable human stem cell lines capable of tissue-specific differentiation and use in the creation of artificial organs.

Research in the field of systems biology and bioinformatics is aimed at solving urgent problems of biology using modern mathematical and computational methods. Of particular relevance is the development of algorithms and programs for highly effective functional annotation of genomes, transcriptomes, proteomes, metabolomes of microorganisms, plants, animals and humans, the creation of theoretical foundations and methodological approaches to the study of network dynamic interactions of biomolecules.

The work in the field of biotechnology will create new effective technologies for industry, agriculture, medicine, environmental management and conservation of natural ecosystems.

Research in the field of synthetic biology is aimed at creating technologies and tools for purposeful modification and construction of genomes in order to create organisms and their components containing biosynthetic pathways not found in nature. As a result of these works, it is planned to develop approaches to the development of technologies for creating completely artificial living organisms in the future.


List of priority areas of fundamental and exploratory scientific research for 2021 - 2030
...
1.6.4. General genetics
...
1.6.4.2. Genomes of economically valuable plant and animal species, identification of genes and gene networks controlling the development of valuable traits for the development of molecular markers for breeding

1.6.4.3. Gene pools of the peoples of the Russian Federation and neighboring countries, human DNA identification, genetic certification of pet breeds and plant varieties
...
1.6.4.5. Epigenetics and epigenomics, the role of epigenetic factors in inheritance and variability of phenotypic traits

1.6.4.6. Genetic control of plant, animal and human development, as well as physiological processes, behavior and cognitive functions
...
1.6.4.8. Marker-oriented genomic breeding and genetic editing of genomes of agricultural plants and animals

1.6.4.9. Genetic and epigenetic markers of early differential diagnosis of socially significant and orphan diseases

1.6.4.10. Genetic aspects of control and change of hereditary information in generations of cells and organisms
...
1.6.5. Soils as a component of the biosphere

1.6.5.1. The impact of global climatic changes and economic activity on the ecological functions of soils, changes in their composition, water-air and thermal regimes
...
1.6.6. Functional microbiology

1.6.6.1. Identification and study of new microorganisms and viruses and their functional role in the biosphere
...
1.6.6.4. Reconstruction of evolutionary relationships and improvement of the systematics of microorganisms based on comparative genomics approaches
...
1.6.6.6. Compositions and principles of functioning of human and animal microbiomes

...
1.6.9. Molecular biology, molecular genetics and genomic research

1.6.9.1. Structural and functional organization and regulation of genome activity of living organisms and viruses
1.6.9.2. Molecular mechanisms of gene expression
1.6.9.3. Structural and functional analysis of genes in norm and pathology

1.6.9.4. Development of genomic editing methods

1.6.9.5. Molecular mechanisms of DNA replication and transcription

1.6.9.6. Molecular mechanisms of DNA repair
1.6.9.7. Structural and functional analysis of the functions of non-coding RNAs, including small and microRNAs
1.6.9.8. Molecular mechanisms of protein biosynthesis and their regulation
1.6.9.9. Organization and expression of genetic material in ontogenesis
...

1.6.11. Systems biology and bioinformatics

1.6.11.1. Modeling of the structure, stability and function of biomolecules and their complexes

1.6.11.2. Algorithms and modeling of molecular genetic, biophysical, ecosystem and biosphere processes

1.6.11.3. Integration and analysis of large arrays ("bigdata") of structural and other biological data

1.6.11.4. Analysis of network dynamic interactions of molecules, supramolecular complexes, organelles and cell structures

1.6.11.5. "Digital cell" - bioinformatic models of cell functioning
...
1.6.12. Biotechnology and synthetic biology

1.6.12.1. Bioengineering and metabolic engineering

1.6.12.2. Medical biotechnologies

1.6.12.3. Agrobiotechnologies

1.6.12.4. Industrial biotechnology

1.6.12.5. Ecobiotechnology

1.6.12.6. Nanobiotechnology"

~~~~
continues...

 

[Lalas]

Распоряжение Правительства РФ от 31.12.2020 № 3684-р

Распоряжение Правительства Российской Федерации от 31.12.2020 № 3684-р "О Программе фундаментальных научных исследований в Российской Федерации на долгосрочный период (2021 - 2030 годы)"

npalib.ru

...
II. Field of scientific knowledge: 2. Technical sciences

Direction of science: 2.1. Construction and architecture

Main scientific tasks and expected breakthrough results for 2021 - 2030

Architecture, urban planning and construction sciences are an area in which technical, technological, aesthetic and other spheres of human activity are intertwined, based on the achievements of fundamental sciences.

The main scientific tasks requiring fundamental scientific research in the field of architecture include [...] the transition to digital technologies in architecture, countering socio-cultural threats.

The main scientific tasks requiring fundamental scientific research in the field of urban planning include the promotion of sustainable development and connectivity of the territory of the Russian Federation[...] the formation of a new set of planning methods - strategic spatial planning of the development of territories, determining the parameters of objects, based on the principle of formation (design) of the development of the national settlement system, including the hierarchy of settlement systems of the Russian Federation, the transition to digital technologies in urban planning.

The main scientific tasks requiring fundamental research in the field of building sciences include the creation of new technologies in the construction and production of building materials, the development of new structural systems of buildings and structures[...] the transition to digital, intelligent production technologies, robotic systems, new materials and methods of construction in construction, ensuring the possibility of an effective response of Russian society to major challenges, taking into account the interaction of man and nature, man and technology, social institutions at the present stage of global development and application of methods of the humanities and social sciences.

***
Directions of science: 2.2. Electrical engineering, electronic engineering, information technology; 2.3. Mechanics and mechanical engineering; 2.4. Medical technologies; 2.5. Energy and environmental management; 2.6. Nanotechnology

Main scientific tasks and expected breakthrough results for 2021 - 2030

The main scientific tasks of the energy sector are aimed at obtaining results in the field of effective development and functioning of energy systems on a new technological basis, modern electrical engineering, pulsed and renewable energy, nuclear, thermonuclear, hydrogen, space and unconventional energy, the transition to environmentally friendly, resource-saving and competitive energy, the study of the impact of energy facilities on the environment and living systems.

The main scientific tasks of mechanical engineering and control processes, including the creation of machines and apparatuses with increased parameters of work processes, theory and technologies of complex systems management will be aimed at the creation and research of machines, machine complexes and complex systems "man - machine - environment", analysis of the dynamics of machines, wave and vibration processes in technology, increasing the resource, survivability and safety of machines and complex technical systems, reducing man-made and technological risks for all objects of the national economy, analysis and synthesis of complex machine complexes, ergonomics and biomechanics of human-machine systems, advanced materials and technologies of mechanical engineering, cybernetics, optimization methods, operations research and artificial intelligence, decision theory, covering the problems of managing systems of various nature, scale and purpose, robotics.

The main scientific tasks of mechanics, in particular general mechanics, navigation systems, dynamics of space bodies, vehicles and controlled vehicles, mechanics of living systems are aimed at studying the dynamics of space bodies and controlled vehicles, mechatronics, the development of principles of movement of mobile robots to move in various environments, the behavior of continuous media taking into account structural transformations, internal and external aerodynamics of high speeds, chemical reactions and phase transitions, shaping technologies, including additive technologies, structural mechanics, geomechanics and technologies for the extraction, transportation and processing of hydrocarbon raw materials, breakthrough technologies for the production of semiconductor materials and heterostructures for nano- and microelectronics, interaction of deformable bodies and the development of theoretical foundations for friction control and increasing the wear resistance of machines and mechanisms, process models in living systems.

The main scientific tasks in the study of nanomaterials and nanoprocesses will ensure the creation of the element base of microelectronics, nanoelectronics and quantum computers to the level of several nanometers, will lead to the possibility of three-dimensional integration and combination of various functional devices in one chip, including using silicon and semiconductor heterostructures, one-dimensional and two-dimensional crystals, metamaterials and biotechnologies.

In order to expand the functionality of various sensors, improve their parameters, simplify technological processes during their manufacture, it is necessary to conduct fundamental and exploratory research in the field of quantum computer science, create hybrid devices based on several physical principles, neuromorphic systems, including those working on new physical principles using the electron charge and its spin, and aimed at integration electronic and photonic technologies. It is necessary to conduct research aimed at implementing multi-element structures based on coherent systems (superconducting quantum bits-qubits) to create connected chains and arrays of qubits that simulate molecular structures, spin dynamics, and other dynamic processes in highly correlated electronic systems. These works will be carried out in relation to quantum macrophysics, mesoscopy, nanostructure physics, spintronics, photonics, plasmonics, superconductivity, acousto-electronics, high-power relativistic microwave electronics, physics of high-power charged particle beams, X-ray optics for synchrotron radiation sources, free electron lasers and neutron optics.

It is required to conduct fundamental research in the field of architecture, system solutions, software, standardization and information security of information and computing complexes and networks of new generations, system programming to create new principles of next-generation software and computer-aided design methodology for a promising element base, including quantum computing, elements with optical transmission of information.

It is planned to conduct fundamental research in the field of automated control systems, in particular, the development of artificial intelligence systems, text extraction and analysis, the development of methods and information technologies of system analysis, methods for the study of complex control systems and processes in conditions of uncertainty and risk. The authors propose the development of methods for finding areas with chaotic dynamics, methods of analysis, stabilization and control for families of systems described by both continuous and discrete equations, the creation and development of a new analytical computer technology for the study, analysis and control of chaotic dynamics of solutions of complex nonlinear systems of differential equations describing numerous natural-scientific and socio-economic processes and phenomena.

The most important tasks include research in the field of computer, information sciences and bioinformatics from the creation of theoretical and methodological foundations, methods, model tools and information technologies of system analysis for the study and evaluation of the prerequisites, course and consequences of socio-economic processes to complexes of mathematical methods, algorithms and programs for detecting and neutralizing malicious code and hidden channels.

In the modern period, it is empirically impossible to create high-tech technical means similar to nuclear reactors, lasers, computers, robots. A prerequisite for their creation is a deep study and knowledge of the physical, chemical and other phenomena and processes underlying the principle of their operation, the creation of mathematical models of these devices, the study of their interaction with humans. The technical level of production determines the degree of use of science, determines the readiness of the technical base of production for the implementation of new scientific ideas. At the same time, the material and technical base of production also creates the material base of scientific research itself, has a decisive influence on the qualitative level of scientific experiments, on the degree of industrialization of science.


Direction of science: 2.2. Electrical engineering, electronic engineering, information technology

List of priority areas of fundamental and exploratory scientific research for 2021 - 2030

2.2.1. Automated control systems
2.2.1.1. General theory of control systems and information management systems, methods and means of communication and network management of multilevel and distributed dynamic systems in conditions of incomplete information
2.2.1.2 Intelligent management systems; knowledge management and systems of interdisciplinary nature, man in the control loop
2.2.1.3. Robotics and automatic control
...
2.2.1.6. Theory and technologies of complex systems management
2.2.1.7. General theory of control systems and information management systems, methods and means of communication and network management of multilevel and distributed dynamic systems in conditions of incomplete information
...

Direction of science: 2.3. Mechanics and mechanical engineering

List of priority areas of fundamental and exploratory scientific research for 2021-2030
...
2.3.2. Mechanical engineering
2.3.2.1. Development of the fundamentals of wave technologies and their applications in mechanical engineering
2.3.2.2. Multi-criteria coherent analysis, ensuring and improving the strength, resource, survivability, reliability and safety of machines, machine and human-machine complexes in interdisciplinary problems of machine science and mechanical engineering. Scientific foundations of structural materials science
...
2.3.2.5. Creation of machines and apparatuses with increased parameters of work processes

2.3.2.6. Development of scientific foundations and means of studying the biomechanics of wave processes in the "man-machine -environment" system, including models of inherited wave and cyclic processes in the human body and ways to increase the biocompatibility of structural materials
...
Direction of science: 2.4. Medical technologies

List of priority areas of fundamental and exploratory scientific research for 2021 - 2030

2.4.1. Medical physics
2.4.1.1. Photonic technologies in medicine
2.4.1.2. Nuclear medicine
2.4.1.3. Development, design and production of biologically active targeted vectors-carriers of radionuclides, research of their radiopharmacological action and safety in the diagnosis and treatment of malignant tumors
2.4.1.4. Development of methods and means of personalized dosimetric planning of radionuclide therapy of malignant neoplasms
2.4.1.5. Development, synthesis and preparation of new highly specific compounds for the prevention of acute radiation syndrome and complications of radiation therapy
2.4.1.6. Nanostructures for medicine
2.4.1.7. Physical diagnostic methods in medicine
2.4.1.8. Cryomedicine
...

Direction of science: 2.5. Energy and environmental management

List of priority areas of fundamental and exploratory scientific research for 2021 - 2030

2.5.1. Energy and environmental management
2.5.1.1. Fundamentals of effective development and functioning of energy systems on a new technological basis in the context of globalization, including problems of energy security, energy conservation and rational development of natural energy resources
2.5.1.2. Systematic studies of the transition to environmentally friendly, resource-saving and competitive energy
2.5.1.3. Physical, technical and environmental problems of energy, heat and mass transfer, thermophysical and electrophysical properties of substances, low-temperature plasma and technologies based on it
2.5.1.4. Fundamental problems of modern electrical engineering, pulsed and renewable energy
2.5.1.5. Interdisciplinary problems of nuclear, thermonuclear, hydrogen, space and unconventional energy
2.5.1.6. Fundamental physical and chemical processes of the impact of energy facilities on the environment and living systems
2.5.1.7. Alternative energy sources, technologies, production and conversion of energy based on renewable sources
2.5.1.8. Determination of a unified comprehensive assessment of the ecological state of a territorial unit as a function of the vulnerability of the components of the natural environment and the intensity of man-made stress for the purpose of environmental forecasting, taking into account the trend of economic development of the region and global warming
...

Direction of science: 2.6. Nanotechnology

List of priority areas of fundamental and exploratory scientific research for 2021 - 2030

2.6.1. Nanomaterials
2.6.1.1. Physical materials science: new materials and structures, one-dimensional and two-dimensional crystals, including fullerenes, nanotubes, graphenes, other nanomaterials
2.6.1.2. Metamaterials
2.6.1.3. Diagnostics of materials and elements of micro- and nanoelectronics

2.6.2. Nanoprocesses
2.6.2.1. Element base of microelectronics, nanoelectronics and quantum computers
2.6.2.2. Materials for micro- and nanoelectronics
2.6.2.3. Nano- and microsystem technology
2.6.2.4. Solid-state electronics
2.6.2.5. Element base for advanced information and computing systems operating on new physical principles
2.6.2.6. Technologies and methods that increase the speed and increase the degree of integration in micro- and nanoelectronics
2.6.2.7. Energy-efficient element base of micro- and nanoelectronics based on one-dimensional and two-dimensional structures for logic circuits, sensors of new generation physical quantities and signal sources
2.6.2.8. Nanotechnologies, nanobiotechnologies, nanosystems, nanomaterials, nanodiagnostics, nanoelectronics and nanophotonics
2.6.2.9. Digital additive three-dimensional technologies

***

III. Field of scientific knowledge: 3. Medical sciences

Direction of science: 3.1. Physiological sciences

Main scientific tasks and expected breakthrough results for 2021 - 2030

The basis for the development of neuroscience is the creation of a scientific platform for the development of artificial intelligence systems of the next generation - neuromorphic artificial intelligence. The platform is designed to overcome fundamental limitations in the capabilities of existing artificial intelligence systems by using the fundamental principles of natural neurocognitive systems. Neuroscience poses a number of new tasks that relate to the study of biological neural networks and those fundamental characteristics of the brain (intelligence, memory and consciousness) and can be transferred to next-generation artificial intelligence systems.

Scientific tasks are relevant, the solution of which will bring us closer to understanding how the brain works, includes the study of the principles of the physiological organization of behavior in the integration of sensory, cognitive and control processes, the formation and storage of memory, brain development in ontogenesis and evolution, neurotechnology of biofeedback for robotic systems and expansion of brain functions, ways to regulate cognitive brain functions normally and in pathology, neurogenetic approaches to brain research.

Promising scientific tasks include the problem of homeostasis, the mechanism of stabilization of the physico-chemical parameters of liquids in the internal environment. The problem of the integrity of the organism in its physiological understanding should become one of the key ones in the new decade, not only in physiology, but also in the life sciences. Understanding the molecular organization of each of the elements of the cells of a living being requires an answer to the question of how the molecular components are combined into a whole, how their regulation is carried out for the purposeful behavior of a person or animal, where disintegration occurs, and how the pathological process, disease develops. Natural intelligence, the birth of thought, the activity of the brain and heart require the stability of the environment surrounding each cell, the creation of an internal environment with minimal fluctuations in parameters is associated with the energy costs of the body. The study of the physiology of homeostasis will open up new opportunities for obtaining the expected breakthrough scientific results and will ensure the identification of patterns of organization of their work in the whole organism, as well as the development of new technologies for highly selective transport of the entire palette of chemical composition of living systems.

The development of new strategies for pharmacological correction of disorders of physiological functions in human diseases based on modern data of genomics, molecular biology and biochemistry, pathophysiology remains an urgent direction.

A promising direction is the search for pathogenetically sound pharmacological methods of regulating receptors and associated signaling cascades, epigenetic processes, ion channels, enzymes, transporters and other physiologically important formations mediating the pharmacodynamics and pharmacokinetics of drugs.

One of the most important scientific tasks of modern physiology remains the transport of various substances through the body, starting with oxygen and nutrients and ending with hormones, cytokines and physiologically active peptides, which provides blood. The expected breakthrough results will allow solving a number of applied tasks on the problems of targeted drug delivery, finding out the causes of rejection of implantable devices. Studies of oxygen transport, immunity, hemostasis, hematopoiesis are the most important fundamental tasks not only of modern physiology, but also of all biology. The solution of these tasks is aimed at creating new methods of therapy and diagnosis of a wide range of socially significant diseases, new methods of drug delivery and their production in the body itself (for example, in erythrocytes-bioreactors), the creation of fundamentally new solutions for blood transfusion with additional functional properties that are necessary for emergency medicine.

Promising scientific tasks include the study of the physiology of the immune system. The development of ways to modulate its mechanisms is relevant and provides opportunities for the development of new areas of medicine, including immunotherapy of oncological diseases.

An important scientific task in the development of diagnostics and monitoring of oncological diseases is the development and creation of diagnostic tests based on the identification and analysis of circulating tumor cells and (or) circulating tumor DNA in peripheral blood, assessment of the profile of non-coding ribonucleic acid RNA in tumor tissue and (or) biological fluids (blood, urine, ascitic fluid and etc.). The tasks related to molecular profiling of tumors are relevant, including the detection of new molecular determinants - driver genes and markers of metastasis, the study of the role of stem cells and signaling pathways controlling metastatic colonization by tumor cells, disorders in which determine the progression of the tumor. A promising direction is to study the proteomic profile of tumor-associated cells, ways of their impact on the primary tumor, as well as factors determining the formation of premetastatic niches, mechanisms and the role of autophagy in the survival of tumor cells. The study of angiogenic and antiangiogenic factors of tumors and features of vasculogenic mimicry remains relevant. The study of the mechanisms of development of drug resistance of tumors will allow obtaining results for use in the synthesis of new generation drugs that will help overcome acquired drug resistance. One of the promising areas of modern fundamental oncology is immuno-oncology, which studies the mechanisms of tumor "care" from immunological "supervision", immunological checkpoints. The result of such studies should be the development of a new generation of antitumor vaccines - T-cell, neoantigenic vaccines.

One of the scientific tasks of modern physiology of the cardiovascular system is to study the processes occurring at the cellular and molecular level (for example, in cardiomyocytes) during ischemia-reperfusion. The study of pathophysiological and functional aspects of hypoxia of the heart, brain and kidneys at the cellular and tissue level, mechanisms and effectiveness of reperfusion of these organs is relevant.

Regenerative medicine is a promising area of biomedicine, whose tasks are to study the physiological processes of regeneration and replacement of tissues and organs lost due to illness or injury. The main areas of regenerative physiology and medicine are cellular physiology, gene therapy, tissue engineering and the creation of artificial organs. Regenerative medicine is an interdisciplinary field that unites cell biologists, biochemists, embryologists, pharmacology and bioethics specialists.

Scientific tasks in the field of space biology, physiology and medicine in relation to long-term space flights beyond the Earth's orbit, as well as the formation of a list of medical risks that space crews of interplanetary missions will face, put plans discussed by space agencies and governments of different countries to send expeditions to the Moon and later to Mars, the organization of long-term functioning planetary settlements there. Solving the tasks set in the field of space physiology and medicine will allow participating in international cooperation of countries involved in the further exploration of outer space and creating new technologies to ensure the life of Russian and international space crews.

Direction of science: 3.1. Physiological sciences

List of priority areas of fundamental and exploratory scientific research for 2021 - 2030

3.1.1. Higher nervous activity, neurophysiology and physiology of cognitive functions
3.1.1.1. Systemic, cellular and molecular mechanisms of memory
3.1.1.2. Interaction of brain neural networks in ontogenesis, learning and brain pathologies
3.1.1.3. Mechanisms of cognitive functions, sleep and consciousness
3.1.1.4. Development of programs and devices that provide the ability to control physical objects according to the parameters of human brain activity
3.1.1.5. Neuroimaging of neurochemical processes in the human brain

3.1.2. Physiology of visceral systems
3.1.2.1. Neurohumoral, molecular-cellular and genetic mechanisms of visceral systems functioning
3.1.2.2. Physiological mechanisms of nervous, hormonal and immune regulation of visceral functions

3.1.3. Physiology of sensory and motor systems
3.1.3.1. Mechanisms of functioning of sensor systems
3.1.3.2. Adaptation of central and peripheral regulation mechanisms to the conditions of changing gravity
3.1.3.3. Integrative mechanisms of sensory-motor regulation of posture and locomotion
3.1.3.4. Management of human motor capabilities and bioprosthetics

3.1.4. Blood physiology
3.1.4.1. Molecular physiology of erythrocytes and transport of gases in the body
3.1.4.2. Physiology of blood clotting and fibrinolysis
3.1.4.3. Hemodynamics and rheology of blood and plasma
3.1.4.4. Hematopoiesis: erythropoiesis and platelet production, plasma protein synthesis

3.1.5. Physiology of the immune system
3.1.5.1. Molecular and cellular mechanisms of immune response regulation
3.1.5.2. Signaling pathways of activation of immune system cells during the formation of an immune response

3.1.6. Fundamentals of oncology
3.1.6.1. Improvement of modern technological platforms for the diagnosis and monitoring of oncological diseases
...
3.1.6.6. Tissue engineering with transplantation of artificially grown autologous tissues and organs

3.1.7. Human ecology: symbionts and infections
3.1.7.1. The role of microflora in the regulation of physiological functions of visceral systems of the body
3.1.7.2. Physiology of human symbiont microorganisms

3.1.8. Physiological mechanisms of genomic regulation
3.1.8.1. Genomic neurotechnologies of selective regulation of nerve cells in certain areas of the brain
3.1.8.2. Plasticity of cells during changes in the microenvironment, differentiation and transdifferentiation of stem and progenitor cells
3.1.8.3. Epigenetic regulation of physiological functions

3.1.9. New strategies for pharmacological correction of violations of physiological functions in human diseases
3.1.9.1. The role of receptors and chaperones in the development of mental diseases and anxiety-depressive disorders
3.1.9.2. Elucidation of the mechanisms of development of heart and vascular diseases for the development of new pharmacotherapy

3.1.10. Physiology of extreme states and gravitational physiology
3.1.10.1. Influence of the Earth's magnetic field and cosmic radiation on physiological systems and cognitive functions
3.1.10.2. Study of the mechanisms of nervous, hormonal and immune regulation of visceral functions in microgravity
3.1.10.3. Mechanisms of adaptation to the factors of long-term space flights of biological objects of various taxonomic affiliation

3.1.11. Evolutionary physiology, development and aging
3.1.11.1. Ways of evolution of nervous, visceral, motor, sensory, endocrine and immune systems
3.1.11.2. Principles of organization and evolution of systems of adaptation of an organism to changing conditions of existence
3.1.11.3. Physiological and cellular mechanisms of embryogenesis and aging
3.1.11.4. Search for effective biomarkers of aging and geroprotectors

3.1.12. Mechanisms of homeostasis, cell renewal and tissue regeneration
3.1.12.1. Fundamental mechanisms of maintaining homeostasis in the body
3.1.12.2. Signaling mechanisms mediating the effect of the microenvironment on cells
3.1.12.3. Cellular and non-cellular components of tissue niches as factors of modification of intercellular interactions
3.1.12.4. The role of fibrosis in the regeneration of organs and tissues
3.1.12.5. Physiology of cell renewal

3.1.13. Physiology of the cardiovascular system; human blood circulation
3.1.13.1. Physiological mechanisms of blood supply to human organs and tissues
3.1.13.2. Compensatory capabilities of a person with impaired blood supply to organs and tissues
3.1.13.3. Regulation of arterial vascular tone
3.1.13.4. Mechanisms of adaptation of cardiomyocytes to ischemia and reperfusion
3.1.13.5. Physiology of baroreceptor activity and autonomic regulation of the cardiovascular system
3.1.13.6. Circulatory systems in critical conditions of the human body"

.....

 

[Lalas]

Распоряжение Правительства РФ от 31.12.2020 № 3684-р

Распоряжение Правительства Российской Федерации от 31.12.2020 № 3684-р "О Программе фундаментальных научных исследований в Российской Федерации на долгосрочный период (2021 - 2030 годы)"

npalib.ru

...
Areas of science: 3.2. Biomedical sciences; 3.3. Clinical medicine; 3.4. Preventive medicine

The main scientific tasks of the development of medical sciences, the solution of which will open up fundamentally new opportunities for obtaining the expected breakthrough scientific results, include the following.

The most important task is to develop indicators, gradations, methods and criteria for assessing the adverse impact of environmental and industrial factors on human health, a system for assessing and managing the risks of developing occupational and environmentally caused diseases, monitoring the health status of the population and the need for medical care in the Russian Federation. Information systems will be developed to predict the impact of environmental factors on health, technologies to reduce the risk of developing environmental-dependent conditions and diseases, monitoring of natural focal infectious diseases, information systems for forecasting and non-drug prevention of production-related, weather-dependent and other diseases, environmental and hygienic requirements for the formation of production zones.

Promising scientific tasks include the creation of highly sensitive analytical methods for identifying and quantifying new and potentially dangerous pollutants of natural and anthropogenic origin in environmental objects, food products and biological environments of the body, the development of methods for managing the risks of contamination with new hazardous substances of environmental objects and food products, including biotechnological origin.

The development of a system for the diagnosis and primary prevention of nutritional status disorders and alimentary-dependent diseases, the creation of therapeutic and preventive nutrition standards for workers in harmful working conditions based on the assessment of nutritional status and data from elemental, genomic, proteomic and metabolomic analysis, the study of the regulatory role of minor biologically active substances in the adaptation of the body, updating the norms of physiological needs will be relevant in energy and food substances for various groups of the population of the Russian Federation, development of technologies for the prevention and treatment of alimentary-dependent human diseases with the introduction of new specialized food products into the diet, including functional drinking waters of directed preventive and health-improving action, development of approaches for correcting the composition of the intestinal microbiota in alimentary-dependent diseases. Research will be conducted aimed at solving problems of food safety, including those obtained with the help of nano- and biotechnologies, principles of personalized diet therapy using gene diagnostics and biomarkers will be developed.

The development of new approaches to the creation of vaccines against diseases caused by pathogens with a high degree of variability and new generations of vaccines based on genetic engineering technologies, methods of reverse genetics and nanotechnology, including tuberculosis, HIV, hepatitis B and C, influenza, will be relevant in the field of microbiology and virology. Diagnostic test systems and express diagnostic methods will be improved and developed, molecular mechanisms of functioning of RNA-containing viruses that cause particularly dangerous diseases of humans and animals, macro- and microevolutions of viral RNA genomes and the structure of a virus-infected cell will be established, new anti-infectious drugs (antibacterial, antiviral chemotherapeutics) will be developed. New therapeutic anti-infective agents based on small interfering RNAs, new approaches to anti-infective therapy based on physical methods of exposure to pathogens, new immunobiological drugs (adjuvants and miniantibodies) will be developed, a system of effective epidemiological surveillance of infectious disease pathogens will be formed, epidemiological models for predictive and analytical studies to assess the prevented incidence of bacterial and viral infections will be created depending on the vaccination coverage of risk groups, catalogs of bacteriophages specific to all significant pathogenic bacteria have been created, new treatment regimens for mycobacteriosis have been developed depending on the type of mycobacterium, the interrelationships of active substances produced by the microbiota and physiological processes in the body, its effect on the development of various pathologies in humans have been studied.

It is planned to create catalogs of bacteriophages specific to all significant pathogenic bacteria, create new generations of vaccines against bacterial and viral infections, study symbiotic microbiocenoses of the digestive tract and the role of the human gut microbiota in norm and pathology, create a federal cryogenic bank of biological samples of natural symbiotic microbiocenoses of the digestive tract of healthy people, identification of targets for new groups of antimicrobial and antiviral drugs based on the study of molecular mechanisms of resistance of microorganisms and viruses to medicinal compounds, creation of new biotechnological methods of multianalysis of resistance of infectious agents.

Promising scientific tasks include the design of a new generation of vector vaccines in order to provide combined protection against ARVI pathogens, the establishment of molecular mechanisms of functioning of RNA-containing viruses that cause particularly dangerous diseases of humans and animals, macro- and microevolution of viral RNA genomes and the structure of a virus-infected cell, creation of a monitoring system for viral hepatitis pathogens and creation of a federal database of circulating strains, development of a computer program for the development of epidemics in Russia, development of methods for stratification of risk groups for the formation of multidrug resistance in patients with infections associated with medical care in order to optimize antibiotic therapy.

The study of molecular mechanisms that provide tumor cells with the ability to form resistance to the therapeutic effect of modern medicines will be relevant in oncology. It is planned to develop and validate modern methods of screening and diagnosis of malignant tumors, the creation of new antitumor drugs, the search for promising targets for antitumor therapy, the development of personalized treatment methods, including using nuclear medicine methods, effective methods of drug delivery to tumors, the determination of genetic mutations - markers of predisposition to oncological diseases, followed by the creation of a database of mutations of the population associated with the risk of developing oncological diseases, and a registry of "patients" - carriers of mutations in the Russian Federation.

The study of the mechanisms of brain development and functioning, plasticity of neurons and glia, neurogenesis and neurodegeneration, learning and memory, intelligence, consciousness and personality, fundamental and applied aspects of socially significant diseases of the nervous system will be relevant in neurology and psychiatry. Neuropsychological, cellular and molecular genetic bases of active longevity, technologies of early diagnosis of neurodegenerative diseases as the basis for preventive neuroprotection will be established. It provides for the creation of new technologies for medical neurointerfaces, the study of the neurophysiological foundations of cognitive activity of the brain, the functions of intelligence, learning and memory. It is planned to study the structural, metabolic, neurophysiological mechanisms of maintaining consciousness and its disorders in focal and diffuse brain diseases with ultrastructural analysis using neuroimaging methods, which will allow using information for machine learning and artificial intelligence technologies. During operations on the human brain, individual neuroanatomy of functionally significant cortical and conductive pathways of the brain will be studied in consciousness. It is planned to create new rehabilitation technologies for acute and chronic diseases of the central nervous system based on the establishment of fundamental mechanisms of brain plasticity. The most significant markers and laboratory tests for predicting the development and course of degenerative-dystrophic pathology of the spine will be identified, an algorithm for combined and hybrid neuroimaging and treatment regimens using virtual and augmented reality will be created.

The development of methods of early diagnosis and personalized treatment of cardiovascular diseases based on the study of cellular-molecular, genetic, neurohumoral, immune and hemodynamic mechanisms of their development, genomic, proteomic and metabolomic studies in the clinic and experiment, the search for epigenetic mechanisms determining the development of myocardial infarction and heart failure based on the analysis of differential expression will be relevant in cardiology regulatory microRNAs and identification of the relationship of polymorphism of genes encoding microRNAs and their targets, as well as epigenome and transcriptome analysis using omix technologies, determination of prognostic markers of atherosclerotic plaque instability and development of methods for predictive molecular diagnostics of acute coronary syndrome, identification of cellular mechanisms of disorders of reparative angioarteriogenesis and regenerative processes in the myocardium, development of the basics of computer analysis of the electric field of the heart using telemetry technology, development of new methods for correcting rhythm disorders hearts (including those with combined pathology), including surgical correction,
the creation of biocompatible implants based on biological and polymer materials for the surgical treatment of diseases of the cardiovascular system using mathematical modeling, tissue engineering techniques and the determination of genomic predictors.
...
The development of non-invasive diagnostic complexes based on functional and laboratory tests for predicting and diagnosing rejection of a heart and liver transplant in the early and long-term after transplantation, the creation of biomedical cellular- and tissue-engineered liver and cartilage products based on composite tissue-specific resorbable matrices, obtaining of epithelial and mesenchymal phenotype of vascularized tissue-engineered structures from postnatal stem cells and human somatic cells to replace bone, cartilage, muscle (including myocardial) and epithelial tissues, development of new techniques for multifactorial three-dimensional nanostructure analysis of biomaterials, cells and tissues using complex scanning probe cryonanotomography.

Promising scientific tasks include the development and improvement of methods of controlled interventions (minimally invasive technologies, transluminal surgery), including the use of robotics, the expansion of the range of combined surgical interventions on several organs and systems using bioengineering methods (the use of combined multicomponent transplants, including autografts and bioengineered structures), the development and improvement of organ transplantation methods and tissues using regenerative medicine technologies, creation of technologies for targeted suppression of transplant immunity and creation of a stable tolerance of the recipient's body to the transplanted organ, development of methods for reconstruction of organs, tissues and limb segments using technologies for cultivation of epithelial tissues, as well as reconstruction of volumetric structures using three-dimensional matrices of specified properties with the possibility of obtaining tissue engineering structures of various properties and structure, development of new innovative technologies for the treatment of extensive burns and wounds using the obtained biotechnological products.

Relevant in the field of personalization of medicine, regenerative medicine, immunology, pharmacology, cellular, genetic engineering technologies will be the creation of new nanoforms of drugs with a qualitatively new level of bioavailability and stability, in particular, the development of therapeutic drugs based on miniantibodies; nanoforms of vaccines, immunobiological and immunoprophylactic drugs; methods for suppressing cell proliferation using nanopreparations.


It is planned to develop and implement modern methods of diagnosis and prevention of rheumatic diseases based on DNA diagnostic methods (mRNA, microRNA and polymorphisms in genomic DNA), identification of immune mechanisms of their pathogenesis based on decoding the structure and spectrum of the most important autoantigens and studying the mechanism of dysfunction of antigen-presenting cells, development of high-capacity selective antigenic sorbents for diagnostic and therapeutic purposes, study of molecular genetic, immunological, biochemical and pharmacological aspects of pathogenesis, diagnosis and treatment of critical conditions.

Promising scientific tasks include the preservation and expansion of the collection of laboratory primates for the purpose of modeling socially significant human diseases and evaluating the quality of medical products.

In the field of postgenomic, proteomic and metabolomic biomedical technologies, methods for making directional changes to genomes using designer nucleases will be developed using the example of 3 - 5 regulatory cascades and the selection of regulatory systems that can have a geroprotective or geroreversive effect, the development of making directional changes to the human genome at the level of isolated cell cultures, the assessment of the influence of age the regenerative properties of stem cells and the development of methods for correcting their disorders using genome editing technologies.

It is planned to search for informative molecular markers (genomic, transcriptomic, proteomic and metabolomic) to assess the risk of occurrence, development and unfavorable prognosis of socially significant diseases, to identify the prevalence of polymorphisms of genes involved in the pharmacokinetics and pharmacodynamics of drugs used for the treatment of cardiovascular diseases and type 2 diabetes mellitus, their relationship with the pharmacinetic characteristics of healthy volunteers and patients with these pathologies, study of physiological substrates and cathepsin inhibitors in the development of malignancy, metastasis and inflammatory processes, development of a systematic approach to the analysis of living objects by combining methods of genomics, transcriptomics, proteomics and metabolomics, bio- and chemoinformatics, creation of methods for measuring proteomic and metabolomic composition in samples of biological material, drug monitoring of major diseases, identification of biomarkers that increase predictive diagnostic potential.

It is relevant to create domestic therapeutic gene technologies, including methods of gene therapy of cardiovascular diseases, malignant tumors (genochemotherapy), as well as technologies for gene correction of hereditary pathology (primarily metabolic defects) and gene therapy constructs for active immunotherapy and immunocorrection, technologies for suppressing the work of damaged genes using antisense oligonucleotides, including short interfering RNAs, molecular-targeted therapy of socially significant diseases with the use of monoclonal antibodies, as well as low molecular weight inhibitors and activators of target proteins, genetic engineering technologies for the production, screening and production of recombinant proteins, including antibodies and miniantibodies, for therapeutic and diagnostic purposes.

A methodology for assessing the biosafety of innovative polymer nanocomposites for medical purposes, based on molecular and cellular changes in the main target organs, and a toxicological passport of new theranostic nanobiocomposites will be developed.

It is expected to obtain new data revealing the role of M1- and M2-macrophages in the regulation of stem cell functions and fibrogenesis, the study of cellular and molecular mechanisms of plasticity of mononuclear phagocytes (monocytes, macrophages, dendritic cells).

It is planned to create viral and non-viral genetic constructs based on the CRISPR/Cas9 genome editing system for knocking out urokinase and urokinase receptor genes in tumor cells, in particular neuroblastoma, to evaluate the possibility of using CRISPR/Cas9 as a new approach for their suppression, to study the effectiveness of different methods of delivering antigenic material to stimulate antitumor material and to choose the optimal tactics for conducting cellular immunotherapy.

It is expected to obtain new data on the molecular regulation of cardiomyocytic differentiation of stem cells on the model of embryonic stem cells and induced pluripotent stem cells, to develop methods for improving the therapeutic properties of postnatal stem cells, to establish mechanisms for the formation of intercellular contacts and proliferative activity, differentiated potential, physiological properties and migration of both single cells and spheroids in the modeling of three-dimensional structural-functional fabrics using natural (natural), synthetic and hybrid structures, development of pharmacological approaches to stimulate the functions of endogenous progenitor cells and tissue regeneration, development of original structure and mechanism of action of drugs (neuropsychotropic drugs, tranquilizers, nootropics, antidepressants, neuroleptics, antiasthenic drugs, alcohol and drug addiction treatment, anti-migraine drugs, treatment of neurodegenerative diseases, neuroprotectors), new medicines for the prevention and treatment of cancer, cardiovascular diseases, diseases of the endocrine system and metabolic diseases, diseases of the digestive system, extreme conditions.

The development of new principles and methods for the isolation and concentration of radionuclides and new technologies for obtaining strategic materials for nuclear medicine will be relevant.


Direction of science: 3.2. Medical and biological sciences

List of priority areas of fundamental and exploratory scientific research for 2021 - 2030

3.2.1. Research of the fundamental foundations of life
3.2.1.1. Integrative foundations of brain activity in normal and pathological conditions
3.2.1.2. Study of the mechanisms of psychoemotional stress and resistance to it
3.2.1.3. Dysregulatory pathology of organs and systems; pathological integrations
3.2.1.4. Investigation of the mechanisms of development of pathological processes in critical, terminal and post-resuscitation conditions
3.2.1.5. Creation of standardized biomodels of laboratory animals
3.2.1.6. Investigation of specific properties of biological molecules in normal and pathological conditions based on modern biomedical technologies using modern biobanking systems and big data
3.2.1.7. Molecular and cellular mechanisms of atherosclerosis pathogenesis and progression of atherosclerotic vascular lesions
3.2.1.8. Study of the participation of mediators, hormones, incretins, autocoids in the integration of the digestive, respiratory, circulatory and excretory systems, clinical application of the results
3.2.1.9. Study of genetic mechanisms of the pathological process formation; study of the genetic structure of the Russian population by "normal" genes and genes of hereditary diseases, creation of biobanks

3.2.2. Postgenomic, proteomic and metabolomic biomedical technologies
3.2.2.1. Investigation of the fundamental mechanisms of aging using genome editing methods
3.2.2.2. Development of molecular profiling methods providing prediction of risks of socially significant diseases
3.2.2.3. Study of the effect of genetic polymorphisms on the pharmacokinetics and pharmacodynamics of drugs in patients with cardiovascular diseases and type 2 diabetes mellitus within the framework of the concept of personalized medicine
3.2.2.4. Study of the functions of biological systems in norm and pathology on the basis of "omix" technologies
3.2.2.5. Studies of structural and functional properties of proteolytic enzymes of cathepsins in normal and pathological conditions
3.2.2.6. Molecular genetic mechanisms of stimulation of neosteogenesis using various osteoinducers
3.2.2.7. Postgenomic digital medicine; metobolomic analysis; genocentric analysis of the human proteome for health assessment
3.2.2.8. Exploring the possibilities of "omix" technologies for the development of personalized therapy for patients with socially significant diseases

3.2.3. Medical cellular and genetic engineering technologies, regenerative medicine
3.2.3.1. Study of the role of stem cells and activation of signaling pathways in the molecular mechanisms of neoplasm formation
3.2.3.2. Development of a methodology for the application of cellular technologies aimed at stimulating reparative processes and modulating the immune response in immunopathological conditions
3.2.3.3. Identification of genes responsible for the occurrence of hereditary and acquired diseases and development of therapy systems based on the introduction of new genetic information into the body to correct genetic defects
3.2.3.4. Research of molecular and cellular bases of regulation of immune response and development of new technologies in cellular immunotherapy of oncological, infectious and autoimmune diseases
3.2.3.5. Creation of standardized biomodels and biobanking systems of biological material
3.2.3.6. Molecular mechanisms of cellular differentiation, immunity and oncogenesis
3.2.3.7. Cellular technologies for the study of molecular mechanisms of pathological processes and improvement of treatment methods
3.2.3.8. 3D bioengineering for the development of the fundamentals of medical technologies, the creation of complex tissues by combining 3-dimensional bioprinting and scaffolding technologies to solve the problems of personalized regenerative medicine
3.2.3.9. Investigation of the mechanisms of stimulation of tissue regeneration, clinical application of the results of these works
3.2.3.10. Creation of therapy technologies and tissue engineering structures based on stem cells
3.2.3.11. Search for autologous tissue analogues, biocompatible polymer materials and development of methods of their clinical application for the treatment of extensive burns and wounds, other pathologies requiring the replacement of significant amounts of tissue
3.2.3.12. Research in the field of biosensor technologies and development of new biosensor systems for the diagnosis and control of the effectiveness of disease therapy
3.2.3.13. Development of new directions in the search for drugs to stimulate the functions of endogenous stem and progenitor cells and tissue regeneration

3.2.4. Pharmacology and pharmacy (pharmacological correction of vital processes)
3.2.4.1. Search and development of vector systems for highly selective delivery of diagnostic and medicinal products to target cells based on antibodies, aptamers, receptors, ligands and other biologically active molecules
3.2.4.2. Creation of container systems for delivery of diagnostic and medicinal products to target cells based on liposomes, micelles, nanoparticles, nanogels and polymer conjugates, as well as on the basis of specific cellular systems
3.2.4.3. Study and creation of genetic systems responsible for the metabolism of drugs, their polymorphism and correlation with individual drug resistance.
3.2.4.4. Creation of means to target the signaling pathways of cell growth factors
3.2.4.5. Study of the molecular mechanisms of chronic inflammatory and reparative processes in cells of organs and tissues; application of biotechnological approaches to create drugs with controlled release of the main drug component
3.2.4.6. Development of new approaches to gene therapy of diseases (including gene therapy of HIV infection)
3.2.4.7. Development of a new generation of antiviral, antibacterial, antiparasitic and antifungal drugs, including biologically active substances (BAS), to overcome resistance to chemotherapeutic drugs
3.2.4.8. Study of genetic markers of sensitivity to pharmacological drugs
3.2.4.9. Development of new principles and methods for the isolation and concentration of radionuclides and new technologies for the production of strategic materials for nuclear medicine
3.2.4.10. Creation of drug screening test systems
3.2.4.11. Search for new molecular targets of pharmacological regulation of pathological processes
3.2.4.12. Study of the mechanisms of interaction of the human body with natural medicinal substances, their combinations with natural therapeutic factors for use in personalized medicine
3.2.4.13. Digitalization of the process of using medicines on the basis of a single platform of decision support systems and the construction of expert systems based on them in order to ensure personalized effective and safe pharmacotherapy and the formation of professional competencies of IT doctors
3.2.4.14. Substantiation and development of new diagnostic methods and medical technologies for intensive advanced therapy of patients with multiple organ dysfunction (insufficiency)
3.2.4.15. Development of a personalized and digital approach to the diagnosis and treatment of socially significant diseases
3.2.4.16. Creation of new technologies for adoptive immunotherapy of patients with tumors


Field of science: 3.3. Clinical medicine

List of priority areas of fundamental and exploratory scientific research for 2021 - 2030

3.3.1. Oncology
3.3.1.1. Identification of genomic, transcriptomic, epigenomic and proteomic genetic markers of oncological diseases
3.3.1.2. Combined treatment of malignant neoplasms, development of algorithms and modes of combined surgical, radiation and drug treatment based on individual molecular genetic profiling
3.3.1.3. Study of molecular and genetic mechanisms of formation of the pathological process of neoplasms
3.3.1.4. Pathogenetic justification, clinical efficacy and safety of epigenome modulators in autoimmune and oncological diseases
3.3.1.5. Study of carcinogenic and molecular genetic effects in long-term dynamics after exposure to various types of ionizing radiation (external gamma neutron and cosmic)
3.3.1.6. Study of molecular genetic mechanisms of hereditary and sporadic colon cancer to optimize personalized approaches to diagnosis, treatment and prognosis
3.3.1.7. Development of new methods of immunotherapy of patients with oncological diseases
3.3.1.8. Search for molecular targets, design and production of biologically active substances (materials), study of their pharmacological action and safety
3.3.1.9. Development of technologies for determining genetic mutations-markers of predisposition to oncological diseases
3.3.1.10. Development and study of methods of gene therapy of malignant neoplasms
3.3.1.11. Development of innovative methods and technologies of personalized cell therapy of patients with oncological diseases

3.3.2. Neurology and Psychiatry
3.3.2.1. Research of integrative bases of pathology of nervous system and mental diseases
3.3.2.2. Investigation of structural, metabolic, neurotransmitter and neurophysiological mechanisms of nervous system plasticity; Experimental modeling of nervous system pathology
3.3.2.3. Reactive changes in the organs of the peripheral nervous system in response to experimental effects and aging
3.3.2.4. Investigation of the role of integrative processes in the central nervous system in the realization of higher forms of brain activity (consciousness, behavior, memory), elucidation of the mechanisms of functioning of sensory and motor systems
3.3.2.5. Development of a model and complex treatment of neurodegenerative diseases
3.3.2.6. Reduction of negative consequences for the health of citizens who have experienced vital stress associated with a threat to life as a result of a terrorist act
3.3.2.7. Studying the mechanisms of adaptation processes in life-threatening situations
3.3.2.8. Study of methods of correction of brain functions associated with aging of the body
3.3.2.9. Study of the etiology and pathogenesis of mental diseases, as well as development of approaches to pathogenetically based therapy of patients
3.3.2.10. Study and development of new approaches to pathogenetically based neurosurgical treatment of patients
3.3.2.11. Research of integrative processes in the human central nervous system in the implementation of higher forms of brain activity (consciousness, behavior, memory) in mosaic realities and at the border of transition (virtual, augmented, mixed), including the study of neurophysiological mechanisms of functioning of sensory and motor systems in mosaic realities
3.3.2.12. Study of neurophysiological features of brain activity in neurodegenerative diseases
3.3.2.13. Computer multimodal modeling of pathological processes and formations of the nervous system based on machine learning and data mining methods

3.3.3. Cardiovascular system
3.3.3.1. Genetic and epigenetic bases of mechanisms of development and progression of cardiovascular diseases
3.3.3.2. Mechanisms of participation of stem cells in reparative/regenerative processes in the heart and blood vessels, theoretical foundations of cellular technologies
3.3.3.3. Epigenetic and genetic interactions in the formation of vascular neoplasms
3.3.3.4. Mechanisms of development of myocardial dysfunction in heart failure and the search for new molecular targets for its correction
3.3.3.5. Study of the role of inflammation in the development and consequences of acute coronary syndrome of vascular catastrophes
3.3.3.6. Cellular and molecular genetic causes of predisposition to the development and progression of atherosclerosis, the search for new methods of its treatment
3.3.3.7. Molecular genetic and physiological mechanisms of arrhythmia development
3.3.3.8. Study and development of new approaches to pathogenetically based surgical treatment of patients with cardiovascular diseases
3.3.3.9. Development of scientific approaches to the application of information technologies in cardiology
3.3.3.10. Development of the basics of a personalized approach to the treatment of patients with cardiovascular diseases"

**** ****
Continues later...

This is a very long, man.
Who made me start it? Who??

 

[Lalas]

It is planned to create viral and non-viral genetic constructs based on the CRISPR/Cas9 genome editing system for knocking out urokinase and urokinase receptor genes in tumor cells,

By the way, this could be a coded language. Maybe someone who knows the code understands that:
"It is planned to create viral and non-viral genetic constructs based on the CRISPR/Cas9 genome editing system for knocking out ukrokinase and ukrokinase receptor genes in tumor cells"

 

[Lalas]

Денис Медоуз - Почетный профессор МГУ

В четверг, 18 ноября, на торжественном заседании Ученого совета профессору университета Нью Хемпшир Денису Медоузу было присвоено звание Почетного профессора Московского университета и вручены диплом и медаль. Это решение было принято Ученым советом в связи с выдающимися достижениями профессора...

www.msu.ru

24/11/2004
Denis Meadows - Professor Emeritus of Moscow State University

On Thursday, November 18, at the solemn meeting of the Academic Council, Professor of the University of New Hampshire Denis Meadows was awarded the title of Honorary Professor of Moscow University and was awarded a diploma and a medal.

This decision was made by the Academic Council in connection with the outstanding achievements of Professor Meadows in creating models of the world dynamics of the development of civilization and many years of successful cooperation with Moscow State University.

Commenting on the decision of the Academic Council, the rector of Moscow State University V.A. Sadovnichy, in particular, said that Denis Meadows is the head of the first project of the Club of Rome and co-author of "The Limits to Growth" (1972) - the first and most famous report of this organization. The research conducted under the leadership of Professor Meadows actually predetermined the development of world thought, concepts and methods of global forecasting and management. The book "The Limits to Growth" has the largest circulation in the history of a book on computer modeling, the only Russian-language edition of which was carried out by the publishing house of Moscow State University in 1990, it was included in the list of the ten most influential works on the environment of the XX century and received the Peace Prize in Germany.

Denis Meadows is an academic advisor in the international program to support the leaders of more than 30 countries, including Russia. He has also been a member of the editorial boards of many professional journals. Meadows' works have been translated into more than 35 languages.

Professor Meadows has repeatedly visited Moscow State University with lectures, demonstrations of simulation predictive models created by him, productively organized cooperation with Moscow State University in the field of natural resource management and the state of the environment.

In response, Professor Meadows expressed his gratitude for the honour bestowed upon him. Then the floor was given to the Dean of the Faculty of Public Administration Alexei Viktorovich Surin and the Dean of the Faculty of Geography Nikolai Sergeevich Kasimov.

In the final part of the meeting, Professor Meadows, according to tradition, left a memorable entry in the Book of Honored Guests.

Виктор Садовничий: в университете приходится учить студентов русскому языку

Ректор МГУ в эксклюзивном интервью «АиФ» — о том, что не так с современной системой образования, в чем советская школа была лучше российской, о «долине МГУ» и о том, как на базе университета будут бороться с допингом в спорте.

www.msu.ru

08/08/17
Victor Sadovnichy: at the university we have to teach students the Russian language

...
[...]And one more thing: for several years I was a member of the Club of Rome, a very well-known international expert organization, whose reports shocked the world, literally turning world politics and economics upside down. Because it was the Club of Rome that first spoke about the exhaustion of the earth's resources, about the threat of environmental shocks. And at the same time, for the first time, they consciously started talking about the fact that two main structures served to preserve humanity from century to century: temples and universities. It was they who ensured its stability and development: spiritual and educational.

Моделирование и прогнозирование глобальных процессов: пределы роста в XXI веке

Очередное мероприятие, прошедшее 15 апреля 2021 года на экспертной площадке Московского университета «Диалог о настоящем и будущем», было посвящено актуальному вопросу об обеспеченности природными ресурсами тех темпов развития цивилизации, которые демонстрирует глобальное человечество в...

www.msu.ru

16/04/2021
Modeling and Forecasting Global Processes: Limits to Growth in the XXI Century

The next event, held on April 15, 2021 at the expert platform of Moscow University "Dialogue about the Present and the Future", was devoted to the topical issue of the provision of natural resources with the pace of development of civilization that global humanity has demonstrated in recent decades.

In the discussion, the preliminary results of the work on the priority strategic project of the Interdisciplinary Scientific and Educational School of Moscow University "Mathematical Methods for the Analysis of Complex Systems" were presented. The dialogue between scientists and researchers was moderated by the Dean of the Faculty of Global Processes of Moscow State University I.V. Ilyin, and representatives of the Faculty of Global Processes and the Institute for Mathematical Research of Complex Systems of Moscow State University acted as experts.

At the beginning of the meeting, I.V. Ilyin noted that the main idea underlying the Faculty of Global Processes, created 16 years ago on the initiative of the Rector of Moscow State University V.A. Sadovnichy, is an interdisciplinary and global approach, the implementation of which makes it possible to train specialists with knowledge in various fields of knowledge - economics, ecology, political science. He recalled the famous 1972 Club of Rome report "The Limits to Growth", about what has changed since that time in the global development agenda. The Dean of the Faculty spoke about the participation of representatives of the faculty in the analysis of global problems, work to resolve them in the spirit of V.I. Vernadsky's concept of the noosphere. I.V. Ilyin noted the special role of Russia, which, on the basis of its millennial experience, can play a decisive role in developing a strategy for the further development of human society.

Professor of the Faculty of Global Processes of Moscow State University S.Y. Malkov spoke about the extensive work being done at Moscow University on mathematical modeling of global processes, within the framework of which there is a scientific understanding and scientific forecast of the trajectories of the possible development of society. [...] The expert formulated Russia's mission – to offer the world an integrating ideology and an integrative economic and geopolitical project in the context of the world's achievement of the limits of growth predicted 50 years ago.

Head of the UNESCO Chair for the Study of Global Problems of the Faculty of Global Processes of Moscow State University, a member of the Club of Rome, Y.N. Sayamov, recalled the pioneering role of Moscow University in discussing the problems of global development, its covenant and, in this regard, the indisputable merits of the graduate of the Faculty of Mechanics and Mathematics N.N. Moiseev, who, together with his American colleague J. Forrestor was one of the originators of the model adopted by the Club of Rome. The expert recalled that today we live in a very dangerous unbalanced world, in which it is scientists who must propose strategies for overcoming the current crisis. Y.N. Sayamov reported on the development by the experts of the Club of Rome of a new report for the 50th anniversary of the first study, which will offer an updated version of the vision of the future world.

Мировое развитие и «пределы роста» в XXI веке: моделирование и прогноз

23 марта 2022 года в рамках спецсеминара «Время, хаос и математические проблемы» ректор МГУ академик РАН В.А. Садовничий и главный научный сотрудник ИМИСС МГУ иностранный член РАН А.А. Акаев представят доклад Римскому клубу «Преодолевая пределы».

www.msu.ru

21/03/2022 Science
World Development and the "Limits to Growth" in the XXI Century:
Modeling and Forecasting

On March 23, 2022, within the framework of the special seminar "Time, Chaos and Mathematical Problems", the rector of Lomonosov Moscow State University, Academician of the Russian Academy of Sciences Viktor Antonovich Sadovnichy and the chief researcher of the Institute for Mathematical Research of Complex Systems of Moscow State University, foreign member of the Russian Academy of Sciences Askar Akaev will present a report to the Club of Rome "Overcoming the Limits".

Since 2009, Lomonosov Moscow State University has been conducting research on modeling and forecasting world dynamics under the leadership of Academician V.A. Sadovnichy and A.A. Akaev. At present, within the framework of the scientific project "World Development and the Limits to Growth in the XXI Century: Modeling and Forecasting", an initiative report has been prepared for the Club of Rome "Overcoming the Limits", dedicated to the fiftieth anniversary of the first report "The Limits to Growth", authored by Donella Meadows, Dennis Meadows, Jorgen Randers and William Behrens. The planned report to the Club of Rome is a Russian view from the standpoint of the first quarter of the XXI century on the solution of the problems that have been discussed by the Club of Rome over the past 50 years.

Time: 6:30 p.m.
Read more: https://expert.msu.ru/haos22-1

Мировое развитие и «пределы роста» в XXI веке: моделирование и прогноз

expert.msu.ru

World Development and the "Limits to Growth" in the XXI Century: Modeling and Forecasting

Presentation of the preprint of the report to the Club of Rome "Overcoming the Limits" Within the framework of the special seminar "Time, Chaos and Mathematical Problems"
23 March 2022, Wednesday

The appearance of the report "The Limits to Growth", as well as subsequent reports, was initiated by the fact that demographic and economic growth in the twentieth century reached a record pace in the entire history of mankind: the world's population increased 4 times over the century, world GDP - almost 20 times. This unprecedented economic and demographic growth has led to a sharp increase in anthropogenic pressure on the environment. In essence, there is a transition from the epoch of the "Holocene" to the epoch of the "Anthropocene", when human activity becomes the main factor in changing the natural environment.

Analyzing the anthropogenic impact on global natural processes, Johan Rockström in 2009 proposed the concept of "planetary boundaries" (GHGs) that define a safe space for human development. These include:
1. climate change,
2. loss of biodiversity,
3. soil degradation,
4. shortage of fresh water,
5. ocean acidification,
6. stratospheric ozone depletion,
7. interference with the circulation of elements,
8. chemical pollution,
9. Aerosol pollution.

Violation of one or more planetary boundaries can be detrimental or even catastrophic because of the risk of exceeding thresholds that will cause nonlinear, abrupt changes in the environment. The authors of the GHG concept found that three processes in the Earth's biosphere — climate change, the rate of biodiversity loss and interference with the nitrogen cycle — have already exceeded their limits.

Western scientists J. Randers, J. Rockström, P.-E. Based on the modeling of socio-natural processes, Stoknes et al. came to the conclusion that the existing models of economic growth, production and consumption inevitably destroy the natural balance and bring the ecological catastrophe closer. They conclude that capitalism as an economic system is unable to stabilize the situation, that it is necessary to change priorities in the development of society from the desire for continuous growth to ensuring socio-natural stability.

Scientists at Moscow State University also came to the conclusion that humanity is now at the turning point of its history. But unlike Western scientists, they believe that the global problems that have arisen are not the limits of growth, but challenges that can and should be overcome. To overcome them, it is necessary, firstly, to direct the emerging technological order (TU) not to the growth of consumption, but to the solution of these global problems and, secondly, the political will of the leaders of the countries of the world is needed to unite efforts, to move from confrontation to cooperation in solving common problems. Humanity must turn the 6th Great Kondratieff Cycle (2018−2050) into a transition cycle from capitalism to post-capitalism, to the formation of a humanistic noospheric society.
~~ ~~ ~~
[*the 6th Great Kondratieff Cycle (2018−2050)

Russia through the hidden eye

https://rigf.ru/en/ The 13th Russian Internet Governance Forum April 6–7 2023 SUPPORTED BY Ministry of Digital Development, Communications and Mass Media of the Russian Federation ORGANIZERS Russian domains .RU and domain space expertise and https://cgitc.ru/en/ SUSTAINABLE FUTURE OF GLOBAL...

vigilantcitizenforums.com

The Sixth Kondratieff Wave and the Cybernetic Revolution
Authors: Grinin, Leonid; Grinin, Anton L.

In the present paper, on the basis of the theory of production principles and production revolutions, we reveal the interrelation between K-waves and major technological breakthroughs in history and make forecasts about features of the sixth Kondratieff wave in the light of the Cybernetic Revolution that, from our point of view, started in the 1950s. We assume that the sixth K-wave in the 2030s and 2040s will merge with the final phase of the Cybernetic Revolution (which we call a phase of self-regulating systems). This period will be characterized by the breakthrough in medical technologies which will be capable to combine many other technologies into a single complex of MANBRIC-technologies (med-bio-nano-robo-info-cognitive technologies). The article offers some forecasts concerning the development of these technologies.
...
The sixth K-wave will probably begin approximately in the 2020s.
...
https://www.weforum.org/agenda/authors/leonid-grinin ]
~~ ~~ ~~

V.I. Vernadsky believed that the noosphere requires global management of planetary processes according to a single rational will. The transition to the noosphere lies through the co-evolution of man and the biosphere. The central requirement of N.N. Moiseev's ecological imperative is the stabilization of the Earth's climate.

Therefore, in their research, scientists from Moscow University focused on analyzing the possibility of solving climate problems and the necessary social transformations to avoid a global crisis and move to noospheric development and an integral humanistic society. The difference between the Russian approach to the analysis of the problems posed in the reports to the Club of Rome is that modern processes are considered not from a distance of several decades, but in a broad macrohistorical context covering hundreds and thousands of years, taking into account the peculiarities of long-term technological development. Based on this analysis, our scientists believe that in the case of solidarity and concerted actions of the world community, the existing problems can be overcome. A really serious scientific task that needs to be solved in order to propose concrete measures to normalize the current ecological situation, in their opinion, is the answer to the question: "What are the permissible limits of the stability of the Earth's biosphere?". Unfortunately, science cannot yet answer it. This is an important area of further research.

«Отвечаем на вызовы – преодолевая пределы». В МГУ прошла презентация препринта доклада Римскому клубу

Виктор Садовничий и Аскар Акаев проанализировали современную ситуацию в мире, представили прогноз развития человечества в XXI веке и предложили новые векторы ре...

scientificrussia.ru

"RESPONDING TO CHALLENGES – OVERCOMING LIMITS." A PRESENTATION OF THE PREPRINT OF THE REPORT TO THE CLUB OF ROME WAS HELD AT MOSCOW STATE UNIVERSITY
24.03.2022

The presented report is a fresh look at the solution of global problems that have been discussed by the Club of Rome for more than half a century. Research on modeling and forecasting of world dynamics has been carried out at Lomonosov Moscow State University since 2009. The authors not only identify the problems of record rates of demographic and economic growth, as well as the critical anthropogenic load on the biosphere, but also put forward scientifically based proposals for a new paradigm of global development.

General provisions and trends

The first report, "The Limits to Growth," was a great success. Demographic and economic growth in the XX century reached a record pace in the history of mankind: the world's population increased over the century by 4 times, and world GDP by 20 times. As a result of rapid economic growth after the Industrial Revolution, the anthropogenic impact on the environment has increased. There was a transition from the Holocene epoch (before the Industrial Revolution) to the Anthropocene epoch (after the Industrial Revolution), when human activity became the main factor in changing the natural environment.

One of the first to realize this fact was V.I. Vernadsky. He proclaimed that humanity has become a powerful geological force and a new state of the biosphere is approaching - the noosphere. Analyzing this, Western scientists have proposed the concept of planetary boundaries that define safe spaces for human development.
...

"Our report now is a Russian view from the standpoint of the current situation of the first quarter of the XXI century, which, of course, is based on previous studies and on our own analytical data," explains Viktor Antonovich.

The rector spoke about Western scientists who, on the basis of socio-natural processes, came to the conclusion that the existing models of economic growth, production and consumption inevitably destroy the natural balance and bring the ecological catastrophe closer. Foreign colleagues see salvation in changing the priorities of the development of society, in the idea that in addition to a market economy, the idea of social care should be present in the world.

"We also came to the conclusion that humanity is currently at the turning point of its history. But unlike our Western colleagues, we believe that the global problems that have arisen are not the limits of growth, but challenges that can and should be tried to overcome," Viktor Antonovich notes.

The domestic approach to the analysis of problems differs, first of all, in the "range of perception". If foreign colleagues from the Club of Rome considered the issues under study in the range of several decades, then the current authors approached the study of the issue within the framework of a broad macrohistorical context covering hundreds and thousands of years:

"Unlike the authors of the Club of Rome, who focused mainly on the physical and biological limits of the planet (finite natural resources bordering on the earth's ability to absorb industrial and agricultural pollution), in our study we try to consider modern processes in a broader macroeconomic context, taking into account the peculiarities of long-term technological development."

In addition, the report warns that humanity's desire for unlimited population growth, consumption of material goods and resources will lead to the collapse of its economic and ecological systems. Scientists conclude that the capitalist system is unable to solve global environmental problems.

"Our study substantiates the conclusion that the main problem lies in the socio-political sphere. And the most important prerequisite for solving common humanitarian problems is the transition from competition between the countries of the world to joint cooperative actions. In this case, most of the problems become not limits to growth, but challenges that can be overcome by joint efforts and targeted technologies," says Viktor Antonovich.

~~ ~~ ~~
[*The deopulation's alternatives, targeted technologies of the Russian antidepopulation strategy:

the cornerstone: "the nature–like technosphere is a part of the noosphere.."

In two words: the common point and the sought end / intermediate goal of all the Sustainable Development Goals, green programs, digitalization, technocracy and transhumanism (of which transgenderism is a part, not the other way around) including genetic programs, mass inoculation, etc. - a peek...

vigilantcitizenforums.com

"KURCHATNIK PRESENTED THE STRATEGY OF MERGING MAN AND MACHINE. HAS KOVALCHUK LAUNCHED A PROJECT TO CREATE "SERVICE PEOPLE"

the cornerstone: "the nature–like technosphere is a part of the noosphere.."

In two words: the common point and the sought end / intermediate goal of all the Sustainable Development Goals, green programs, digitalization, technocracy and transhumanism (of which transgenderism is a part, not the other way around) including genetic programs, mass inoculation, etc. - a peek...

vigilantcitizenforums.com

Draft Decree of the President of the Russian Federation "On the Strategy for the development of nature-like (convergent) technologies" (full text)
...
Convergence of sciences and technologies – integration, fusion of sciences and technologies, their methods and approaches, allowing to obtain results that are fundamentally unattainable within each of the converging sciences and/or technologies separately. Currently, convergent sciences and technologies include a group of NBICS technologies (nano-, bio-, information, cognitive, socio-humanitarian technologies), but the list is open and can be expanded later.

Nature–like technologies are technologies that reproduce systems and processes of wildlife in the form of technical systems and technological processes integrated into the natural resource turnover. Convergent NBICS technologies are tools for creating nature-like technologies.

...
The noosphere is a new, evolutionary state of the biosphere, in which scientific and technological human activity becomes a determining factor in the development of the biosphere.

Socio–humanitarian technologies are the processes of research and modification of the spiritual world of an individual in connection with its social functions and manifestations.

........

the cornerstone: "the nature–like technosphere is a part of the noosphere.."

https://www.atomic-energy.ru/about The scientific and business portal "Atomic Energy 2.0" is the largest and most visited progressive digital media of the nuclear industry in Russia and the CIS countries, published in cooperation with many business, scientific, government, educational, public...

vigilantcitizenforums.com

08 February 2023
Prime Minister Mikhail Mishustin signed an order approving a five-year program of activities of the National Research Center "Kurchatov Institute". The federal budget has already allocated more than 185 billion rubles for its implementation.
...
page 23
"The Program's activities are aimed at obtaining breakthrough scientific and technological results in order to ensure the security, technological independence and competitiveness of the country, achieve national development goals and implement strategic national priorities.

Special attention will be paid to research and development in the field of nature-like technologies that reproduce systems and processes of wildlife in the form of technical systems and technological processes integrated into the natural resource turnover. The advanced development of nature-like technologies as the basis for the creation of a nature-like technosphere, leading to a change in technological structure, is a key factor in ensuring Russia's technological leadership in the medium and long term.
...
software and hardware means of natural communication with robotic devices based on human-machine interfaces and methods of effective interaction of devices
..
bioreactors (chips)
..
development of group robotics systems with elements of social behavior with intelligent and hybrid control systems based on biosimilar technologies
..
bioelectronic and biosensor devices
..
(etc.)

the cornerstone: "the nature–like technosphere is a part of the noosphere.."

https://www.atomic-energy.ru/about The scientific and business portal "Atomic Energy 2.0" is the largest and most visited progressive digital media of the nuclear industry in Russia and the CIS countries, published in cooperation with many business, scientific, government, educational, public...

vigilantcitizenforums.com

*]
~~ ~~ ~~

Among the negative characteristics of modern reality, the rector mentioned instability, geopolitical conflicts, governance crises and trade wars at the international level. In order to overcome modern challenges, it is necessary to direct the emerging sixth technological order not to increase consumption, but to search for solutions to problems within the framework of post-capitalism and noospheric thinking, the mechanism of which should be the political will of the leaders of the countries of the world to stop confrontation and unite efforts in solving common problems.

Mathematical models and forecasts

Askar Akayev delved into the history of the formation of modern challenges and forecasting their development with the help of mathematical models. The speaker identified 7 areas in which calculations were made:

climate (air pollution),
ecology (environmental pollution),
economics
demography
Technology.
social sphere,
politics.

The scientist paid special attention to the problem of global warming and the impact of energy strategies on this issue. He noted that the results of the Paris and Kyoto conferences, as well as the summit in Glasgow, were taken into account before searching for possible solutions, so that the options could not only hypothetically neutralize the problem, but also take into account the real capabilities of the countries.

Of the positive trends among the existing energy strategies, the scientist noted the course towards the use of renewable energy sources (RES). However, an abrupt abandonment of the usual coal, gas and oil can also have a negative impact and deal a blow to the economies of countries. For the transition to be painless, it is necessary not to abandon the old stations, but to stop building new ones. It is also necessary to neutralize coal emissions using modern technologies, which will reduce efficiency, but will be the right step towards solving the environmental problem.

The scientist noted that before everyone counted the energy consumed, and in this case, the number of people who consume energy is considered. The forecast is based on the concept of a demographic and technological imperative: the pace of technological development is proportional to the population. One of the best forms of energy production was named mobile nuclear power plant as a future symbiosis of renewable and nuclear energy.

Askar Akayev also made a prediction about artificial intelligence. In addition to the well-known fear that artificial intelligence will deprive people of specific professions of jobs, the scientist clarified that the consequences could be much more serious:

"For the first time, we see the presence of intelligent machines. They began to take away from us the work of analyzing, producing, and using information. It follows that in the twenty-first century, intelligent machines will not only take away our jobs, but for the first time will begin to contribute to population reduction. Whether we will be able to stabilize in these conditions, while no one knows [...] Reports from the Club of Rome claim that population growth is a disaster. It is necessary to vary, reduce the birth rate and take control into our own hands. On the contrary, we came to the conclusion that humanity should now think about how to stop the depopulation of human civilization.

At the end of his speech, Askar Akayev presented the developed strategies for solving urgent problems:

· transition to a fair globalization;

· fair international trade;

· reform of the financial system;

· transition to a green economy;

· social innovations;

· the fight against social inequality around the world.

Viktor Antonovich noted that the report is debatable in nature and expresses the author's point of view. According to Askar Akayev, the Club of Rome willingly cooperates with Russian colleagues. The full report in English will be presented in the fall and, according to tradition, will be published by Springer, and the book in Russian language will be published this summer."

 

[Lalas]

 

[Lalas]

Decree of the President of the Russian Federation of November 4, 2020
№ 666 "On reducing greenhouse gas emissions"

10 November 2020

In order to implement the Paris Agreement of December 12, 2015 by the Russian Federation, I decide:

1. The Government of the Russian Federation shall:

a) to ensure by 2030 a reduction in greenhouse gas emissions to 70 percent compared to the 1990 level, taking into account the maximum possible absorption capacity of forests and other ecosystems and subject to sustainable and balanced socio-economic development of the Russian Federation;

b) develop, taking into account the characteristics of economic sectors, the Strategy for the socio-economic development of the Russian Federation with low greenhouse gas emissions until 2050 and approve it;

c) ensure the creation of conditions for the implementation of measures to reduce and prevent greenhouse gas emissions, as well as to increase the absorption of such gases.

2. This Decree shall enter into force on the date of its official publication.

President of the Russian Federation V. Putin
The Kremlin, Moscow
November 4, 2020
№ 666

Document Overview
By 2030, it is planned to reduce greenhouse gas emissions by up to 70% compared to the 1990 level, taking into account the maximum possible absorption capacity of forests and other ecosystems.

The Strategy for the Socio-Economic Development of Russia with Low Greenhouse Gas Emissions until 2050 will be approved.

The decree comes into force from the date of publication.

Указ Президента РФ от 4 ноября 2020 г. № 666 “О сокращении выбросов парниковых газов” | Документы ленты ПРАЙМ: ГАРАНТ

Документы ленты ПРАЙМ: Указ Президента РФ от 4 ноября 2020 г. № 666 “О сокращении выбросов парниковых газов” | ГАРАНТ

www.garant.ru

 

[Lalas]

SCIENCE AND TECHNOLOGY
"The Kurchatov Institute guarantees our sovereign existence"

What challenges and opportunities were discussed at the conference dedicated to the 80th anniversary of the scientific center

«Курчатовский институт гарантирует наше суверенное существование»

Какие вызовы и возможности обсуждали на конференции, посвященной 80-летию научного центра

iz.ru

23 August 2023

The greatest danger today is not nuclear weapons, but biological threats. However, the work of the Kurchatov Institute ensures that Russia will find answers to these challenges. This was stated by the President of the National Research Center "Kurchatov Institute" Mikhail Kovalchuk at the conference "Kurchatov Institute in Defense of the Fatherland. History, Modernity, Future". Among other topics discussed by the participants of the conference were the main directions of development of domestic science and advanced Russian developments.

Main threats
The conference, dedicated to the 80th anniversary of the Kurchatov Institute and the 120th anniversary of its founders Igor Kurchatov and Anatoly Alexandrov, was held as part of the program of the international forum "Army-2023".
...
At the same time, the President of the Research Center stressed that the main priority for the Kurchatov Institute is the development of nature-like technologies and research in the biological field.

- Today, there are hundreds of American laboratories around the world - it is already obvious to everyone what they are doing ... The creation of biological weapons is moving to a new level," said Mikhail Kovalchuk.

He assured that "the modern Kurchatov Institute guarantees our sovereign existence in the XXI century in the same way as in the XX, responding to both nuclear and biological hazards."

...
And Andrei Fursenko, Assistant to the President of Russia, who concluded the conference, noted the importance of the main task set by the Kurchatov Institute.

- The movement towards nature-likeness is a matter of human survival: will we learn to live in peace with nature or will we not be able to rebuild ourselves, our approaches? The convergence of different sciences in order to ensure peaceful coexistence with nature is something that the Kurchatov Institute has been very actively engaged in lately. I believe that this may be the most important opportunity and the most important challenge for humanity," he stated.

Andrei Fursenko also noted that the Kurchatov Institute plays an important role in the popularization of science, in the promotion of new ideas and knowledge.

- The Kurchatov Institute holds the flag. This is very important, and on my birthday I wish that this flag would never be lowered," the presidential aide concluded.

***

Курчатовский институт проведет Международный форум конвергентных и природоподобных технологий

Курчатовский институт проведет Международный форум конвергентных и природоподобных технологий

nrcki.ru

The Kurchatov Institute will hold the International Forum of Convergent and Nature-Like Technologies

25.08.2023
In October 2023, Russia will host the International Science and Technology Forum of Convergent and Nature-Like Technologies. It will be organized by the National Research Center "Kurchatov Institute".

Among the main tools for the development of nature-like technologies are synchrotron and neutron research methods that allow working with substances at the atomic level, as well as genetic technologies.
In Russia, both of these areas are developed within the framework of federal scientific and technical programs, where the Kurchatov Institute is the leading scientific organization.

Within the framework of the Forum of Convergent and Nature-Like Technologies, the main venue of which will be the House of Scientists House of Scientists named after Academician A.P. Alexandrov, the following events will take place:

– International Scientific and Educational "Kurchatov Genomic Forum" (KurchatovGenTech-2023), October 17 – 20. The purpose of the event is to consolidate efforts in the development of domestic genetic technologies. The program includes a youth conference "Genetic and Radiation Technologies in Agriculture", which will be held on October 19-20 at the site of the National Research Center "Kurchatov Institute" - VNIIRAE in Obninsk (Kaluga Region).

- Visiting meeting of the Public Council of the Basic Organization of the CIS Member States for the Development of Megascience Research Infrastructure: October 23. Among the topics of discussion is the development and expert evaluation of scientific programs of organizations from the CIS countries, involving research projects at megascience facilities.

– Kurchatov Forum for Synchrotron Neutron Research (Kurchatov FSNI-2023): October 24 – 27. Within the framework of the event, it is planned to hold a round table "Program for the Development of Research Capabilities of the Kurchatov Synchrotron and Neutron Research Complex", thematic sections and symposia.

We invite our colleagues to take part in the Forum. Detailed information about its events will appear on the website of the National Research Center "Kurchatov Institute".

Press Center of the National Research Center "Kurchatov Institute"

Открыта регистрация на Курчатовский геномный форум

Открыта регистрация на Курчатовский геномный форум

nrcki.ru

Registration for the Kurchatov Genomic Forum is open
25.08.2023

NRC "Kurchatov Institute" invites you to the Kurchatov Genomic Forum ("KurchatovGenTech-2023"), which will be held in Moscow, at the House of Scientists named after Academician A.P. Alexandrov, from October 17 to 20.

Within the framework of the forum, four sections are planned:

– "Applied Genomics";

– "Fundamental genomics";

– "Biosafety and ensuring technological independence";

– "Genetic technologies for business".


In addition, the KurchatovGenTech 2023 program includes:

scientific and practical conference "Bioresource collections: current state and potential for the creation of new technologies and innovative products in the Russian Federation";
round tables devoted to the activities of world-class genomic research centers and national bioresource centers, the creation of a domestic instrument base for genetic research, regulatory legal regulation and training of highly qualified personnel;
meeting of the technical committee "Viticulture and winemaking".

During the forum, the "Vinology" platform will work, the theme of which is the popularization of the domestic science of viticulture and winemaking.

Another event of the forum will be the youth conference "Genetic and Radiation Technologies in Agriculture", which will be held on October 19-20 at the site of the National Research Center "Kurchatov Institute" - VNIIRAE (Obninsk, Kaluga region).

An application for participation in the forum as a participant or listener can be sent here: https://genrussia.ru/genforum#registration

"KurchatovGenTech - 2023" will be held within the framework of the International Scientific and Technological Forum of Convergent and Nature-Like Technologies, which is organized by the National Research Center "Kurchatov Institute".

Press Center of the National Research Center "Kurchatov Institute"

 

[Lalas]

Year 2007.
2007.
_____
Order of the Ministry of Industry and Energy of the Russian Federation dated August 7, 2007 “On Approval of the Strategy for the Development of the Electronic Industry of Russia for the period up to 2025”

https :// www .garant.ru/products/ipo/prime/doc/91853/

At the end of Point 3.:

"Forecasts of electronics development for the post-silicon period [!!!!?](after 2020)[!!!!?] suggest the widespread introduction of nanotechnology achievements in industry.
..
[!!!]The introduction of nanotechnology should further expand the depth of its penetration into the daily life of the population. [!!!!!] There must be a constant connection of each individual with global information and control networks such as the Internet.[!!!!!]

[!!!!!!!!] NANOELECTRONICS WILL INTEGRATE WITH BIOLOGICAL OBJECTS and provide continuous control over the maintenance of their vital functions, improving the quality of life, and thus reduce the social costs of the state. [!!!!!!!!!]

[!!!!!!!!!] Embedded wireless nanoelectronic devices that ensure constant human contact with the intellectual environment surrounding him will become widespread, and means of direct wireless contact of the human brain with objects surrounding him, vehicles and other people will become widespread. [!!!!!!!] The circulation of such products will exceed billions of pieces per year due to its widespread distribution.

[!!!!!!!!!]The domestic industry should be ready for this challenge, since the ability to produce all components of network systems will mean the establishment of actual control over all their users, which is unacceptable for many sides from the point of view of preserving their sovereignty.[!!!!!!!!] A similar point of view is shared by EU experts in connection with the global expansion of electronics manufacturers from Southeast Asian countries and the intention of the United States to secure permanent technological leadership in this area. Therefore , in the period 2016-2025 . we should expect another strengthening of the role of electronics in the life of society and be economically ready for a new round of global competition of countries based on nanoelectronic technology.

4. Main program activities

...[At the end of Point 4.:]

[!!!!] At the third stage (2016-2025) [<-!!!!!]The strategy is supposed to be implemented within the framework of a new federal target program, which will be developed taking into account the implementation of the Federal Target Program "Development of electronic component base and radio electronics" and provide for:

- gaining significant positions in a number of sectors of the global electronic component base market;

- [!!!!!!!!] widespread introduction of the achievements of domestic nanotechnology, bioelectronics and microsystem technology in everyday human life in the fields of healthcare, education, housing and communal services, transport and communications.[!!!!!!!!]

..
6. Conclusion
The implementation of a complex of interrelated special subprograms, investment projects and extra-programmatic activities that form the basis of the proposed Strategy will restore the scientific, technical, production and technological potential of the electronic industry as a whole and bring it to the modern world level.
..
The reconstruction and technical re-equipment of key electronic equipment production facilities and the optimization of the industry structure on the basis of public-private partnership with the simultaneous creation of market infrastructure should ensure a significant improvement in the economic situation of organizations and increase the profitability of products.

Taking into account the high potential level of domestic science in the field of electronics [!!!] by 2025, we can expect a significant development of international scientific and technical cooperation and a breakthrough in the field of new technologies, including nanotechnology, bioelectronics, optoelectronics, quantum computers, etc.[!!!]
..

Minister of Industry and Energy
Of the Russian Federation V.B. Khristenko
Order of the Ministry of Industry and Energy of the Russian Federation dated August 7, 2007 “On approval of the Strategy for the Development of the Electronic Industry of Russia for the period up to 2025”

The text of the order was published in the newspaper " Weekly of Industrial Growth " dated September 24-30 , 2007 N 31

"Order of the Ministry of Industry and Energy of the Russian Federation dated August 7, 2007 “On Approval of the Strategy for the Development of the Electronic Industry of Russia for the period up to 2025”

https :// www .garant.ru/products/ipo/prime/doc/91853/

At the end of Point 3.:

"Forecasts of electronics development for the post-silicon period [!!!!?](after 2020)[!!!!?] suggest the widespread introduction of nanotechnology achievements in industry.
..
[!!!]The introduction of nanotechnology should further expand the depth of its penetration into the daily life of the population. [!!!!!] There must be a constant connection of each individual with global information and control networks such as the Internet.[!!!!!]

[!!!!!!!!] NANOELECTRONICS WILL INTEGRATE WITH BIOLOGICAL OBJECTS and provide continuous control over the maintenance of their vital functions, improving the quality of life, and thus reduce the social costs of the state. [!!!!!!!!!]

[!!!!!!!!!] Embedded wireless nanoelectronic devices that ensure constant human contact with the intellectual environment surrounding him will become widespread, and means of direct wireless contact of the human brain with objects surrounding him, vehicles and other people will become widespread. [!!!!!!!] The circulation of such products will exceed billions of pieces per year due to its widespread distribution."

25.08.2023

Обнаруженный учеными ЛЭТИ эффект позволит создавать компактные вычислительные системы на новых физических принципах

Исследователи показали, что с помощью одного СВЧ-сигнала можно управлять характеристиками другого передающего информацию сигнала. Эффект был достигнут благодаря применению принципов магноники – перспективному разделу электроники, изучающему свойства магнитных материалов.

etu.ru

The effect discovered by ETU "LETI" scientists will make it possible to create compact computing systems based on new physical principles

Researchers have shown that with the help of one microwave signal, it is possible to control the characteristics of another signal transmitting information. The effect was achieved through the application of the principles of magnonics - a promising branch of electronics that studies the properties of magnetic materials.

Modern electronics, operating on the basis of a silicon component base, today is approaching the limit of its capabilities in a number of important characteristics, including energy efficiency (and as a result, a tendency to overheat), performance and compactness. Therefore, scientific groups around the world are actively developing alternative approaches to building electronics based on new physical principles.

Magnonics acts as a scientific basis for the creation of a new generation of computing systems. This direction studies the use of fundamental excitations of the magnetic system - spin waves and their quasi-particles magnons as information carriers (by analogy with current in electronics or with light in radio photonics). Such physical phenomena occur in magnetic materials.

Magnonica offers promising approaches to overcoming the critical limitations of current technologies, as they can provide ultra-low power operation and energy independence. However, the creation of computing devices based on the principles of magnonics, in particular, requires the development of effective methods for controlling wave effects in magnetic materials.

"We have learned to control one of the characteristics of the magnon flow with the help of another magnon flow. This principle of operation is based on the effect of induced nonlinear phase shift of waves and is a fairly simple and effective solution for changing the parameters of a high-frequency signal transmitting information.

Head of the Laboratory of Magnonics and Radiophotonics, Professor of the Department of Electrotechnical Physics of ETU "LETI" Alexey Borisovich Ustinov

According to the scientist, the induced nonlinear shift allows you to control the phase - this is one of the characteristics with which you can modulate the signal in data transmission and processing systems. The effect was demonstrated in the laboratory on a one-dimensional magnon crystal made from a film of yttrium iron garnet (ZHIG), a widespread magnetic material.

Based on the collected data, a mathematical model was compiled that shows how the induced nonlinear phase shift works. The results of the work are published in the scientific journal Applied Physics Letters:

Nonlinear phase shifts induced by pumping spin waves in magnonic crystals

A nonlinear phase shift of low-power spin waves (SWs) induced by a high-power pumping SW excited both inside and outside the magnonic band-gaps of a magnonic cr

pubs.aip.org

"In fact, the effect we have demonstrated can be used to create compact phase shifters based on the principles of magnonics. In the future, such elements can be used in the construction of artificial neural networks, computing devices, as well as in the development of physical reservoir computers."

Head of the Laboratory of Magnonics and Radiophotonics, Professor of the Department of Electrotechnical Physics of ETU "LETI" Alexey Borisovich Ustinov

The development of the methodology, component base and prototypes of devices based on new physical principles at ETU "LETI" is carried out at the Laboratory of Magnonics and Radio Photonics named after B.A. Kalinikos, which was established at ETU "LETI" in 2021 as part of a megagrant from the Government of the Russian Federation. Earlier, as part of this work, the laboratory staff developed a nonlinear phase shifter based on the ZHIG film, acting on the principles of magnonics."

the cornerstone: "the nature–like technosphere is a part of the noosphere.."

St. Petersburg State Electrotechnical University "LETI" named after V.I.Ulyanov (Lenin) SPbGETU "LETI" https://prioritet2030.etu.ru/ MISSION AND STRATEGIC GOAL OF SPbSETU "LETI" within the framework of the PRIORITY 2030 program The mission of the University is to ensure the scientific and...

vigilantcitizenforums.com

St. Petersburg State Electrotechnical University "LETI" named after V.I.Ulyanov (Lenin)
SPbGETU "LETI"

MISSION AND STRATEGIC GOAL OF SPbSETU "LETI"
within the framework of the PRIORITY 2030 program
...
According to Viktor Anatolyevich, the results of the nanoheterostructure research project are the basis for the development of devices used in ultrafast and intelligent information systems capable of transmitting large amounts of information. Such equipment is currently being developed at LETI within the framework of the strategic project "New technologies of information connectivity of objects and territories".

"On the other hand, the production of such new components, the development and use of these communication systems rests on the need to process huge amounts of information. Classical artificial intelligence may not be able to cope with this task or solve it insufficiently effectively. For this purpose, as part of our third strategic project, we have developed the concept of a strong hybrid co-evolving, which will be able to develop in close conjunction with the user, based on his individual requests and characteristics. A new type of artificial intelligence will be in demand primarily in medicine and pharmaceuticals."
Vice-Rector for Scientific Work of SPBSET "LETI" Viktor Anatolyevich Tupik
...
The goal of the project is to enter the labor division system of the TOP 5 clusters (R&D + production) in the global NewRadio| 6G market by 2030, in terms of creating new principles and structural components of the NET–2030 ultra-broadband high-speed communication networks, including cognitive, hybrid, adaptive reconfigurable, heterogeneous, solving the problem of mastering new frequency bands, including subTHz.
...
Development of hardware and software complexes of the Internet of Everything (IoE) for the ecosystem of NET-2030 networks.
..
The aim of the project is to develop the fundamentals of Strong Hybrid Intelligence (SHI) with the construction of a technological stack based on it for the intellectualization of economic sectors and its testing in the field of applied medicine.

Objectives of the strategic project
Fundamental research. Development of a mathematically based concept of strong hybrid intelligence; approaches to ensuring the interoperability (compatibility) of human and machine intelligence in solving complex problems; principles of modeling and description of cognitive functions.
..
1.2.The concept of interoperability (compatibility) of interacting intelligent agents based on human and machine intelligence at different levels (neural interfaces, cognitive and semantic communication).
..
Development of "smart" photonic sensors and networks based on them for the construction of human-machine systems using hybrid intelligence technologies, including unmanned aircraft systems.
..

 

[Lalas]

President of the Kurchatov Institute Mikhail Kovalchuk gave a lecture at USPTU

Президент Курчатовского института Михаил Ковальчук выступил с лекцией в УГНТУ

nocrb.ru

03.07.2023
Mikhail Kovalchuk, President of the National Research Center "Kurchatov Institute", paid an official visit to USPTU and gave a lecture for scientists of the Eurasian REC on the topic "Science and Technology in the Modern World".

The event was attended by Chairman of the Federation Council Committee on Science, Education and Culture Lilia Gumerova, Head of the Administration of the Head of the Republic of Bashkortostan Maxim Zabelin, Advisor to the Head of the Republic of Bashkortostan on Science Ruslan Kazykhanov, public figure Karine Khabirova and other officials.

The rector of the university, Oleg Baulin, presented Mikhail Kovalchuk with a diploma of awarding the title of "Honorary Professor of USPTU": "It is a great honor for us that the head of such a large scientific center of the country as the Kurchatov Institute, with its vast scientific experience in various fields, visited our university and became our Honorary Professor!" he said.

Mikhail Kovalchuk – President of the Kurchatov Institute, Doctor of Physical and Mathematical Sciences, Professor, Corresponding Member of the Russian Academy of Sciences, a leading scientist in the field of X-ray physics, crystallography and nanodiagnostics, one of the ideologists and organizers of the development of nanotechnology in Russia, head of the interdepartmental working group in the direction of "Priority and Interdisciplinary Scientific Research" of the Presidential Council for Science and Education.

He began his two-hour lecture with the words: "Today Russia has the most perfect system of organizing science in the world!" The speech was devoted to the explanation of the key principles of the development of domestic science, its tactical and strategic priorities, the most important of which, according to the lecturer, are nature-like technologies and the fusion of humanitarian and technical knowledge. Modern civilization is acquiring a new image, determined by atomic and space projects. Mikhail Kovalchuk told the audience about the global challenges of our time, which determine the sustainable development of civilization, about the unique developments of domestic scientists in the field of nuclear energy. He also noted that an important problem of the modern world is the antagonism of nature and the technosphere, the main solution of which is nature-like technologies, which are designed to return human developments to the natural cycle.

Mikhail Kovalchuk, President of the National Research Center "Kurchatov Institute":

"Russia has something to be proud of in any field of science. In nuclear technology, we are ahead of the rest of the world, in genetics we have always been very good, then we lagged a little behind, and now, I think, we are catching up, and soon there will be a breakthrough! Because Russian scientists have a huge potential. We have a great country and a great science, so it was and so it is! Today, we prioritize specific areas because we are limited in time and resources. Therefore, the most striking breakthroughs will be in these areas. We have a unique document approved by the President of the Russian Federation – the Strategy for Scientific and Technological Development of the Russian Federation – which formulates the global challenges facing humanity in the 21st century and ways to respond to them. We are well aware of these challenges: the lack of resources, food, energy, clean drinking water, and so on. This is how a specific priority arises: if you do not have enough energy, then you need to develop nuclear energy, alternative energy, the oil industry, and achieve deep processing of everything in order to preserve the environment. Russia is a huge country, which has no analogues in the world, and in order to work together on priority scientific areas, it is necessary to develop transport, the mobility of academic personnel, space technologies, forming common goals and implementing them. Our science today is the youngest science in the world or one of the youngest. Over the past 5-8 years, the number of young people in science has increased significantly. Surveys show that more than 50% of parents, thinking about the future of their children, believe that they should go into science, that is, a huge influx of young specialists is expected! This is a wonderful generation, talented people! The only thing left to do is to work – all together: both the old and the young. Let's work!"

the cornerstone: "the nature–like technosphere is a part of the noosphere.."

In two words: the common point and the sought end / intermediate goal of all the Sustainable Development Goals, green programs, digitalization, technocracy and transhumanism (of which transgenderism is a part, not the other way around) including genetic programs, mass inoculation, etc. - a peek...

vigilantcitizenforums.com

Nature-like and Convergent Technologies as drivers for the Fourth Industrial Revolution | UNIDO Knowledge Hub

The twenty-first century has presented mankind with a number of major challenges that threaten the sustainable development of civilization. In order to overcome these challenges, new approaches to development must be found. What do we call major challenges? These are the problems and...

hub.unido.org

 

[Lalas]

Russia's contribution to the ecology of the future was discussed at the forum "Eco Altai. The Thread of Nature"

https://iz.ru/1582985/2023-10-02/vklad-rossii-v-ekologiiu-budushchego-obsudili-na-forume-eko-altai-nit-prirody

October 2, 2023
The session "Ecology of the Future Begins in Russia", dedicated to the country's contribution to the formation of global environmental policy, was held on the second day of the international forum "Eco Altai. The Thread of Nature".

The session was moderated by Albina Dudareva, Ambassador of the Women's Union of Russia.

The panellists noted that any negative impact on the environment, if not compensated, leads to a reduction in biodiversity. In this context, it is important to think not only about the preservation of those species of animals and plants that are in plain sight.

"The danger to a much greater extent lies in the fact that species whose names none of us know, which live in the soil and water, are disappearing in huge numbers. For example, 1 cubic centimeter of fresh or sea water at a temperature of 5 to 45 degrees is home to 1 million living creatures. It is these producers and decomposers that create biomass that play the main role in the life of the biosphere," said Viktor Danilov-Danilyan, a Russian scientist, economist, ecologist, hydrologist, corresponding member of the Russian Academy of Sciences, urging to focus on preserving the biodiversity ecosystem formed over thousands and millions of years.

Experts drew attention to the fact that ensuring sustainable environmental development requires, among other things, the mobilization of the existing intellectual potential of specialists in a wide range of natural and social sciences.

"The main task is to remove the conflict between the biosphere and the technosphere, to build them on the principle of coexistence, and then their convergence will take place," said Raif Vasilov, President of the Society of Biotechnologists of Russia, Doctor of Biological Sciences, Professor. According to him, it is possible to transform the technosphere created and used by man on the basis of nature-like technologies, and such developments are available, in particular, by specialists of the National Research Center "Kurchatov Institute".

The day before, within the framework of the forum, the issue of developing a new strategy for environmental safety was discussed. During today's session, participants assessed the potential time frame for work on this document. "I reaffirm and will insist that it is necessary to start creating a new environmental safety strategy as soon as possible and try to extend it as far as possible, perhaps until 2050. And, of course, it is necessary to do it by 2025," said Valery Fadeev, Adviser to the President of the Russian Federation, Head of the Presidential Council for the Development of Civil Society and Human Rights (HRC).

Participants in the discussion came to the conclusion that it is necessary to create new platforms to discuss environmental issues and one of them could be the BRICS summit, which will be held in 2024 in Kazan."

***

the cornerstone: "the nature–like technosphere is a part of the noosphere.."

In two words: the common point and the sought end / intermediate goal of all the Sustainable Development Goals, green programs, digitalization, technocracy and transhumanism (of which transgenderism is a part, not the other way around) including genetic programs, mass inoculation, etc. - a peek...

vigilantcitizenforums.com

Draft Decree of the President of the Russian Federation "On the Strategy for the development of nature-like (convergent) technologies"

the cornerstone: "the nature–like technosphere is a part of the noosphere.."

In two words: the common point and the sought end / intermediate goal of all the Sustainable Development Goals, green programs, digitalization, technocracy and transhumanism (of which transgenderism is a part, not the other way around) including genetic programs, mass inoculation, etc. - a peek...

vigilantcitizenforums.com

Stage 1. Formation of the scientific and personnel base for the development of nature-like (convergent) sciences and technologies (2022-2026).
Priority tasks of the stage:
..
- development and creation of combined (hybrid) technical systems and technological processes using natural components, primarily biosensors, biofuel elements, brain-computer interfaces, additive technologies for creating separate biosimilar and artificial biological objects, nuclear medicine and radiation therapy technologies;
...

the cornerstone: "the nature–like technosphere is a part of the noosphere.."

In two words: the common point and the sought end / intermediate goal of all the Sustainable Development Goals, green programs, digitalization, technocracy and transhumanism (of which transgenderism is a part, not the other way around) including genetic programs, mass inoculation, etc. - a peek...

vigilantcitizenforums.com

Stage 2. Creation of technological foundations for the beginning of the formation of separate nature–like scientific and production clusters (2027-2032).

Priority tasks of the stage:
...
- synthetic biology (artificial cell, artificial virus);

- biophotonic devices;

- biorobots;
..
- energy supply systems for implantable devices, artificial organs and biorobots due to energy processes in living organisms;

- development and creation of neuromorphic brain-machine and brain-brain interfaces, anthropomorphic bioprostheses, anthropomorphic robotic devices;

- development and creation of neuromorphic artificial intelligence systems, including those with the ability to self-study without connection to data storage and processing centers;
__
Stage 3. Formation of the basic elements of the nature–like technosphere (2033-2037).

Priority tasks of the stage:

- transfer of the results of stages 1 and 2 to the economy;

- technological reproduction of systems and complexes of wildlife, first of all:

- nature-like energy systems, including nature-like nuclear power;

- cyberphysical additive production complexes ("Internet of everything");

- medical systems based on technologies of correction of the psychophysiological sphere of a person;

- formation of basic elements of anthropomorphic biorobotonics, including communities of anthropomorphic biorobototechnical systems;

- creation of super-large neurocomputers based on the developed neuroprocessors, approaching the human in their cognitive capabilities;

- creation of a new generation of artificial intelligence systems with cognitive capabilities, providing approaches to creating a "strong" artificial intelligence;
....."

the cornerstone: "the nature–like technosphere is a part of the noosphere.."

https://www.atomic-energy.ru/about The scientific and business portal "Atomic Energy 2.0" is the largest and most visited progressive digital media of the nuclear industry in Russia and the CIS countries, published in cooperation with many business, scientific, government, educational, public...

vigilantcitizenforums.com

The Government of the Russian Federation approved the 185-billion program of the Kurchatov Institute for 2023-2027
...
The main areas of work provided for in the program are the development of nuclear technologies for the creation of a new generation of nuclear energy, research and development in the field of creating new materials, including electronic component base, the use of nuclear technologies in medicine, research in the field of genetics and biotechnology, as well as the creation of nature-like technologies.
...
Special attention will be paid to research and development in the field of nature-like technologies that reproduce systems and processes of wildlife in the form of technical systems and technological processes integrated into the natural resource turnover. The advanced development of nature-like technologies as the basis for the creation of a nature-like technosphere, leading to a change in technological structure, is a key factor in ensuring Russia's technological leadership in the medium and long term. ........
(revew)

 

[Lalas]

At the forum "EcoAltai. The Thread of Nature" named the main components of environmental sovereignty

На форуме «ЭкоАлтай. Нить природы» назвали основные составляющие экологического суверенитета

В Горно-Алтайске открылся международный форум «ЭкоАлтай. Нить природы». В течение двух дней участники обсудят, какие решения сегодня необходимы для достижения экологического суверенитета, как вовлечь бизнес в этот процесс, а также сделать экопредпринимательство интересным для молодежи. Форум...

asi.ru

September 29, 2023

In Gorno-Altaisk, the international forum "EcoAltai. The Thread of Nature". Over the course of two days, participants will discuss what solutions are needed today to achieve environmental sovereignty, how to involve business in this process, and how to make eco-entrepreneurship interesting for young people. The forum is organized by the Government of the Altai Republic, the Roscongress Foundation, and the Altai Republic Development Center with the support of the Agency for Strategic Initiatives (ASI).

According to the head of the Altai Republic, Oleg Khorokhodin, the main components of environmental sovereignty are the green economy and finance, environmental thinking, environmental education and new standards in environmental education. All these areas are already being implemented in the region.

"The Altai Republic, first of all, is a territory of sustainable development. We identified the environment as the point of our economic growth even before it became a trend, and we continue to improve and finalize our strategic documents in accordance with new challenges," said Oleg Khorokhodin.

The concept of noosphere development of the republic has been developed - a system of views on the management of regional development, taking into account the needs of the population, resources, environmental and economic opportunities of the region. "The Republic of Altai is becoming a pilot region in this matter, the experience of implementing the concept of noosphere development can be extended to other subjects and countries within the framework of national and Eurasian cooperation programs," the head of the region added.

The head of Sberbank, Herman Gref, spoke about the role of business in preserving Russia's natural resources. Sberbank actively finances green projects, including the development of the Manzherok resort in Altai, based on the principles of caring for the environment. "Rosstat has estimated the value of natural resources in our country at 104 trillion rubles. This is 19% of all the national wealth of our country. And, obviously, this is something that we have to use very carefully. We are now doing a lot to open Altai to the residents of our country. And all this is subordinated to two key goals - the preservation of the cultural and historical traditions of the Altai people and the improvement of health," said Herman Gref.
..."

 

[Lalas]

https://iz.ru/1569708/andrei-korshunov/pobeda-za-nano-ustoichivye-mikroby-dezinfitciruiut-sharikami-i-almazami

8 September 2023
Victory for Nano: Resistant Microbes Are Disinfected with "Balls" and Diamonds
How Effective New Remedies Against Bacteria Will Improve Humanity's Safety

Russian scientists have synthesized a molecular antimicrobial complex that is promising for creating disinfectants for complex and delicate materials. It is possible that in the future, drugs based on it will be able to become an effective replacement for antibiotics. In addition, the composition includes nanodiamonds capable of luminescence. Due to this, the new macromolecule can become the basis for the development of phototherapy treatments for cancerous tumors. Experts told what needs to be done to bring the development to implementation in medicine and other areas.

Sensitive to light
A method of combating bacteria resistant to antibiotics was developed by scientists from the national research center "Kurchatov Institute" — St. Petersburg Institute of Nuclear Physics (NRC "KI" — PNPI) named after B.P. Konstantinov together with colleagues from St. Petersburg State University and Orenburg Medical University.

The method is based on the properties of substances that become active when exposed to light. As such, the scientists used fullerenes, complex spherical carbon molecules about a nanometer in size. These ultra-small "balls" easily penetrate the cell and convert visible light into energy, which excites reactive oxygen species and oxidizes the cell's internal environment. As a result, the pathogenic microorganism dies.

Tubes with antimicrobial complex solution
Photo: NRC "Kurchatov Institute"

To enhance the effect, the scientists combined fullerenes with nanodiamonds. They stabilize the active ingredient in the biological environment and increase the antimicrobial activity of the complex. Another important component is a medical polymer that serves as a model for natural macromolecules and acts as a carrier of biologically active substances (polyvinylpyrrolidone).

IZVESTIA REFERENCE
The new molecular complex was developed at the Research Center "KI" – PNPI by specialists of the Laboratory of Neutron Physical and Chemical Research under the leadership of Vasily Lebedev and the Laboratory of Experimental Genetics headed by Svetlana Sarantseva. The molecular structure was synthesized by process engineer Lyudmila Lisovskaya. The effect of the new drug on pathogenic microorganisms was first studied by the staff of the Department of Microbiology, Virology, Immunology of the Orenburg Medical University, headed by Elena Mikhailova.

As Olga Bolshakova, a specialist of the Department of Molecular and Radiation Biophysics of the Research Center "KI" - PNPI, told Izvestia, in the course of the research, the ability of the obtained structure to counteract bacteria and microscopic fungi was assessed. In all cases, she showed a high result. The macromolecule also confirmed its effectiveness against the formation of biofilms (complex bacterial communities), which traditional antibiotics cannot always cope with.

"All components of the complex have a pronounced antimicrobial effect, but their combined effect turned out to be much stronger," Olga Bolshakova noted.

According to Alexander Vul, Head of the Laboratory of Physics of Cluster Structures at the Ioffe Institute of Physics and Technology, the action of the new molecular complex is based on the fact that fullerenes easily attach to the cell wall of microbes, affect its integrity and, penetrating inside, cause oxidative stress. At the same time, fullerenes can accumulate in the shell. The antimicrobial activity of nanodiamonds is also associated with an effect on the cell wall.

A new generation of drugs
Scientists see the prospect of further work with the new complex in the creation of an alternative to well-known modern antibacterial drugs on its basis. For example, antibiotics.

"The search for new antimicrobial agents is becoming more and more urgent. This is due to the growing resistance of bacteria to the drugs currently in use. Fullerenes can become a means of effective counteraction to microbial infections," Olga Bolshakova explained.

She noted that the prospects for using carbon nanoparticles (fullerenes and diamonds) in this capacity are based on the specifics of damage to the cellular structure, to which microbes have not yet adapted.

Scientists also believe that a new generation of disinfectants can be created on the basis of the macromolecule, which will be able to fight contaminants resistant to traditional drugs. Medical institutions and laboratories are constantly faced with this problem. Another important area of their application can be the disinfection of surfaces that require particularly careful handling (for example, exhibits in a museum).

"We are living in the era of the end of the golden age of antibiotics. They can no longer fully protect humanity from infections. Therefore, any alternative is welcome. Be it fullerenes, antibodies, bacteriophages (viruses for bacteria – Izvestia) and other antimicrobial agents. They increase the period of safe existence of mankind," Pavel Nazarov, a senior researcher at the A.N. Belozersky Research Institute of Physical and Chemical Biology of Moscow State University, commented on the scientists' study.

However, he noted that there is a long way to go from the stage of discovering useful properties in biostructures to the creation of a medical product based on them, which includes laboratory and clinical research, patenting and certification. In particular, it is necessary to study the mechanism of action of the new complex. Bacteria have different cell walls and metabolic pathways. Therefore, each species requires a different type of impact to eradicate them.

Currently, the team of the Department of Microbiology of the Orenburg State Medical University, headed by Elena Mikhailova, is engaged in solving these problems. Activities in the university's laboratory are supervised by Rector Igor Miroshnichenko.

Cancer Treatment Method
Another vector of research of the new macromolecule is related to the development of drugs for targeted antitumor therapy on its basis. The method is based on the ability of nanodiamonds to luminesce, i.e. to glow, under the influence of X-rays. Inside the human body, this light will excite fullerenes, which, in turn, will provoke the work of reactive oxygen species to oxidize and destroy cancer cells.

Olga Bolshakova suggests that the technique will not be toxic to humans due to the fact that the active substances are inactive in the dark, and the X-ray radiation that excites them will be directed directly to the areas affected by the tumor.

"The versatility of the complex opens up wide opportunities for the use of fullerenes in medicine. In particular, as a means of targeted delivery of drugs to the affected areas. The development has advantages over many other types of nanoparticles and nanocrystalline systems that are currently being studied," said Kristina Kotyakova, a researcher at the Inorganic Nanomaterials Research Center of the University of Science and Technology of MISIS.

Alexander Vul, in turn, noted that in the near future it is necessary to focus on the development of a new generation of disinfectants, as well as products to protect against skin infections.

"The creation of such drugs is easier, since they are not intended to be injected into the body and do not require detailed tests. However, the necessary research should be carried out in this direction to confirm the effectiveness of new disinfectants compared to analogues," the scientist said.

He added that the development of drugs that work inside the body is a long-term goal. In the world, medical corporations spend an average of 8-10 years to create a commercially successful drug. Also, research requires significant financial investments."

 

[Lalas]

Nanobrass Pattern: "Columns" Will Protect Prostheses and Chips from Infections
Can the new coating of implants rid the body of bacteria during implantation?

https://iz.ru/1561100/andrei-korshunov/nanobrannyi-uzor-stolbiki-zashchitiat-protezy-i-chipy-ot-infektcii

August 20, 2023

Scientists have created coatings for implants that can reduce the possibility of their contamination by microbes by 10 times. The effect is achieved due to nanostructuring, as a result of which ultra-small bulges (columns) placed in a special way prevent the formation of bacterial colonies on the surfaces of devices implanted in the body. The effectiveness of the coatings has been experimentally confirmed on model strains of bacteria. Experts note the relevance of the development, but believe that it needs to be tested on a wide range of pathogenic microbes.

Antimicrobial bollards
The Moscow Institute of Physics and Technology (MIPT) has developed a coating that will help protect implants, devices made of inorganic materials that are implanted into the human body, from microbial contamination. This is an urgent problem, since such devices are widely used in modern medicine, cosmetology and some other areas.

Implants are mainly used to replace defects in living tissues. The most well-known types are prostheses for joints and internal organs, cardiac stimulators, and blood vessel wall substitutes. They are also used, for example, to enlarge women's breasts or implant under the skin in the form of microchips.

Photo: Courtesy of MIPT Press Service

According to data published in peer-reviewed medical journals, the number of infections caused by infection of implant devices in European countries exceeds 100,000 per year. In general, about 5% of such structures in the world contain foci of pathogenic microorganisms.

The essence of the method proposed by Moscow scientists is to cover the devices with a special pattern. It consists of convexities in the form of nanocolumns, placed in a special order. These ultra-small structures prevent bacteria from settling on the surface and forming biofilms (as microbial colonies are called).

"The diameter of the columns is 500 or 700 nanometers, and the distance between them is twice as large. Moreover, these parameters are an order of magnitude smaller than the size of bacteria. It is inconvenient for microbes to settle on such a needle-like surface," Maria Barshutina, co-author of the development and senior researcher at the Center for Photonics and Two-Dimensional Materials at MIPT, told Izvestia.

She explained that if the bacterium rests on the columns, its shell will stretch. At the same time, 15% tension is enough for it to burst. As a result, the microorganism dies.

During the research, scientists experimentally confirmed that the bacterial population is reduced by 10 times on patterned nanostructured coatings compared to flat surfaces.

Mother-of-pearl iridescence
Currently, scientists use the method of soft lithography to create antibacterial coatings. This is a method of manufacturing ultra-small structures using special elastic dies.

"We create a mold with notches, which we fill with polymer. When we release it, we get a coating with a corresponding convex pattern," explained Maria Barshutina.

She added that the columns themselves are too small to be seen with the naked eye. To do this, you need an electron microscope. Or atomic power to estimate them in volume. To the ordinary eye, a rainbow play will be visible, similar to mother-of-pearl iridescence. They occur as a result of the refraction of light, since the dimensions of the structures are comparable to the wavelength of light.

Specialists from the MIPT Center for Photonics and Two-Dimensional Materials shared their findings with the expert community by publishing a corresponding article.

https://www.tandfonline.com/doi/abs/10.1080/08927014.2023.2228206

Currently, scientists continue their research, experimenting with patterns — the shape of nanocolumns and their location relative to each other to obtain the greatest antibacterial effect. Experts are also looking for ways to create a cost-effective coating technology to implement it in the mass production of implants.

"Countering microbial foci on implants is important because biofilms are very resistant to antimicrobial agents. Even multi-stage disinfection is often unable to fully protect patients from infections," commented Stella Evstigneeva, a junior researcher at the Institute of Biochemistry and Physiology of Plants and Microorganisms of the Russian Academy of Sciences.

In her opinion, the development will improve the safety of implants and reduce the likelihood of their bacterial contamination. At the same time, thanks to the comparatively cost-effective method of lithography, it will be possible to obtain nanostructured materials with a wide range of applications of various properties.

In addition, experts note the difficulty of fighting infections that occur due to infected implants.

"Such infections can cause inflammation of internal tissues and provoke chronic diseases, as well as lead to the failure of devices implanted inside the body. They can be the cause of death," explained Kristina Kotyakova, a researcher at the Research Center for Inorganic Nanomaterials at MISIS University.

The expert added that when implants are infected, antimicrobial therapy in the form of pills or injections is necessary. And in severe cases, surgery and device replacement are required. However, revision surgery may also prove ineffective due to antibiotic-resistant strains and the high likelihood of reinfection on the new implant.

Therefore, the method of nanostructuring the surface is really relevant, the expert believes. At the same time, she noted that in order to introduce it into medical practice, it is necessary to expand research and test the obtained coatings on a larger sample of pathogenic bacteria."

 

[Lalas]

ТГУ поможет устойчивому развитию Алтая – экологической столицы России

Национальный исследовательский Томский государственный университет — старейший университет Сибири, входит в ТОП-100 лучших вузов мира.

news.tsu.ru

04.10.2023
TSU will help the sustainable development of Altai, the ecological capital of Russia

Tomsk State University can initiate the creation of an innovative scientific and technological center "Noosphere" in the Altai Republic. This region is officially recognized as the ecological capital of Russia: five natural areas of the republic are included in the list of natural heritage sites of UNESCO. The creation of the Noosphere ISTC will contribute to the sustainable development of the territory, the emergence of effective nature-like technologies in the country and ensuring the socio-economic stability of the region.

– TSU received from the Head of the Altai Republic, Oleg Khorokhordin, the right to act as the lead organization when submitting the application of the Noosphere project to the Russian government. The decision was made by the head of the republic not by chance," said Alexander Vorozhtsov, TSU Vice-Rector for Research and Innovation. "The driving force of the Noosphere ISTC will be scientific knowledge about this unique region, where an innovative scientific and technological center will appear. This information is accumulated at TSU, the first university in Siberia, which almost a century and a half ago began studying this macroregion in general and the Altai Mountains in particular.

The large-scale scientific groundwork created by Tomsk State University in this area was presented at the International Forum "Eco Altai. The Thread of Nature". In particular, it was noted that TSU scientists at the end of the 19th century began to study the biodiversity of the flora and fauna of Altai. Currently, these studies are carried out within the framework of the interdisciplinary project "Global Changes of the Earth: Climate, Ecology, Quality of Life" with the support of the federal program "Priority 2030".

One of the focuses of this strategic project is the study of the melting of Altai glaciers, which has a significant impact on the climate of the entire planet. Tomsk scientists began glaciological studies of glaciers in 1914. A few decades later, the research was significantly expanded thanks to the appearance of the TSU Aktru research station. Now the station is one of the best high-altitude research sites in Russia.

"One of the main tasks of the Noosphere ISTC is to ensure the sustainable development of the Altai Republic, in particular, the development of organic agriculture technologies, nature-like technologies, new approaches for the health of the nation and for the longevity of Russians," says Lyudmila Borilo, Director of the Siberian Institute for the Future of TSU. "TSU is already implementing a number of projects aimed at achieving these goals.

In particular, on the basis of the Advanced Engineering School "Agrobiotech" of TSU, technologies for processing waste into valuable products are being created, TSU chemists have developed several new catalysts for processing CO2. Comprehensive studies of the carbon cycle, the main component of greenhouse gases, are being carried out at the site of the carbon test site in the Tomsk Region.

Combining the professional competencies and accumulated experience of TSU scientists and their Altai colleagues will ensure a synergistic effect and ensure the dynamics of the development of the areas identified as key for the Noosphere ISTC.

It should be added that at present, a special working group, formed by order of the head of the Altai Republic, is engaged in solving issues related to the creation and development of the Noosphere ISTC. The group included representatives of the Government of the Altai Republic, TSU, SAGU and the Interdepartmental Analytical Center."

 

[Lalas]

SCIENCE AND TECHNOLOGY
"The Kurchatov Institute guarantees our sovereign existence"

What challenges and opportunities were discussed at the conference dedicated to the 80th anniversary of the scientific center

«Курчатовский институт гарантирует наше суверенное существование»

Какие вызовы и возможности обсуждали на конференции, посвященной 80-летию научного центра

iz.ru

23 August 2023

The greatest danger today is not nuclear weapons, but biological threats. However, the work of the Kurchatov Institute ensures that Russia will find answers to these challenges. This was stated by the President of the National Research Center "Kurchatov Institute" Mikhail Kovalchuk at the conference "Kurchatov Institute in Defense of the Fatherland. History, Modernity, Future". Among other topics discussed by the participants of the conference were the main directions of development of domestic science and advanced Russian developments.

Main threats
The conference, dedicated to the 80th anniversary of the Kurchatov Institute and the 120th anniversary of its founders Igor Kurchatov and Anatoly Alexandrov, was held as part of the program of the international forum "Army-2023".
...
At the same time, the President of the Research Center stressed that the main priority for the Kurchatov Institute is the development of nature-like technologies and research in the biological field.

- Today, there are hundreds of American laboratories around the world - it is already obvious to everyone what they are doing ... The creation of biological weapons is moving to a new level," said Mikhail Kovalchuk.

He assured that "the modern Kurchatov Institute guarantees our sovereign existence in the XXI century in the same way as in the XX, responding to both nuclear and biological hazards."

...
And Andrei Fursenko, Assistant to the President of Russia, who concluded the conference, noted the importance of the main task set by the Kurchatov Institute.

- The movement towards nature-likeness is a matter of human survival: will we learn to live in peace with nature or will we not be able to rebuild ourselves, our approaches? The convergence of different sciences in order to ensure peaceful coexistence with nature is something that the Kurchatov Institute has been very actively engaged in lately. I believe that this may be the most important opportunity and the most important challenge for humanity," he stated.

Andrei Fursenko also noted that the Kurchatov Institute plays an important role in the popularization of science, in the promotion of new ideas and knowledge.

- The Kurchatov Institute holds the flag. This is very important, and on my birthday I wish that this flag would never be lowered," the presidential aide concluded.

***

Курчатовский институт проведет Международный форум конвергентных и природоподобных технологий

Курчатовский институт проведет Международный форум конвергентных и природоподобных технологий

nrcki.ru

The Kurchatov Institute will hold the International Forum of Convergent and Nature-Like Technologies

25.08.2023
In October 2023, Russia will host the International Science and Technology Forum of Convergent and Nature-Like Technologies. It will be organized by the National Research Center "Kurchatov Institute".

Among the main tools for the development of nature-like technologies are synchrotron and neutron research methods that allow working with substances at the atomic level, as well as genetic technologies.
In Russia, both of these areas are developed within the framework of federal scientific and technical programs, where the Kurchatov Institute is the leading scientific organization.

Within the framework of the Forum of Convergent and Nature-Like Technologies, the main venue of which will be the House of Scientists House of Scientists named after Academician A.P. Alexandrov, the following events will take place:

– International Scientific and Educational "Kurchatov Genomic Forum" (KurchatovGenTech-2023), October 17 – 20. The purpose of the event is to consolidate efforts in the development of domestic genetic technologies. The program includes a youth conference "Genetic and Radiation Technologies in Agriculture", which will be held on October 19-20 at the site of the National Research Center "Kurchatov Institute" - VNIIRAE in Obninsk (Kaluga Region).

- Visiting meeting of the Public Council of the Basic Organization of the CIS Member States for the Development of Megascience Research Infrastructure: October 23. Among the topics of discussion is the development and expert evaluation of scientific programs of organizations from the CIS countries, involving research projects at megascience facilities.

– Kurchatov Forum for Synchrotron Neutron Research (Kurchatov FSNI-2023): October 24 – 27. Within the framework of the event, it is planned to hold a round table "Program for the Development of Research Capabilities of the Kurchatov Synchrotron and Neutron Research Complex", thematic sections and symposia.

We invite our colleagues to take part in the Forum. Detailed information about its events will appear on the website of the National Research Center "Kurchatov Institute".

Press Center of the National Research Center "Kurchatov Institute"

Открыта регистрация на Курчатовский геномный форум

Открыта регистрация на Курчатовский геномный форум

nrcki.ru

Registration for the Kurchatov Genomic Forum is open
25.08.2023

NRC "Kurchatov Institute" invites you to the Kurchatov Genomic Forum ("KurchatovGenTech-2023"), which will be held in Moscow, at the House of Scientists named after Academician A.P. Alexandrov, from October 17 to 20.

Within the framework of the forum, four sections are planned:

– "Applied Genomics";

– "Fundamental genomics";

– "Biosafety and ensuring technological independence";

– "Genetic technologies for business".


In addition, the KurchatovGenTech 2023 program includes:

scientific and practical conference "Bioresource collections: current state and potential for the creation of new technologies and innovative products in the Russian Federation";
round tables devoted to the activities of world-class genomic research centers and national bioresource centers, the creation of a domestic instrument base for genetic research, regulatory legal regulation and training of highly qualified personnel;
meeting of the technical committee "Viticulture and winemaking".

During the forum, the "Vinology" platform will work, the theme of which is the popularization of the domestic science of viticulture and winemaking.

Another event of the forum will be the youth conference "Genetic and Radiation Technologies in Agriculture", which will be held on October 19-20 at the site of the National Research Center "Kurchatov Institute" - VNIIRAE (Obninsk, Kaluga region).

An application for participation in the forum as a participant or listener can be sent here: https://genrussia.ru/genforum#registration

"KurchatovGenTech - 2023" will be held within the framework of the International Scientific and Technological Forum of Convergent and Nature-Like Technologies, which is organized by the National Research Center "Kurchatov Institute".

Press Center of the National Research Center "Kurchatov Institute"

The Kurchatov Institute will hold the International Forum of Convergent and Nature-Like Technologies

Biosafety issues were discussed at the Kurchatov Genome Forum

На Курчатовском геномном форуме обсудили вопросы биобезопасности

На Курчатовском геномном форуме обсудили вопросы биобезопасности

nrcki.ru

18.10.2023
Fundamental issues of genome study and applied genetic research, the results of the work of world-class Russian genomic centers and the development of bioresource centers - all these topics are discussed at the Kurchatov Genome Forum (KurchatovGenTech-2023), which began work on October 17 at the NRC "Kurchatov Institute".

"KurchatovGenTech-2023" is held as part of the International Forum of Nature-Like Technologies. The organizer is the National Research Center "Kurchatov Institute".

The central event of the first day was the plenary session "Genetic Technologies: Towards Industry Solutions through Fundamental Knowledge". The main topic is biosecurity.

The rapid development of biotechnology creates not only opportunities for humanity, but also threats.
"Thanks to the advent of physics in biology, today we are on the verge of creating completely new, nature-like technologies. Science has the ability to intervene in the process of evolution. The first way is to create artificial biological systems. You can create an artificial cell, and it will be a super-effective drug. But on the other hand, weapons of mass destruction can also be created in this way. Another way is to change the genome of living objects, and this can also be used both for good and for harm,"
commented Mikhail Kovalchuk, President of the Kurchatov Institute, the keynote speaker and moderator of the meeting.

As M. Kovalchuk emphasized, risk factors are an increase in the availability of biotechnologies in the absence of effective control over their spread and application. At the same time, international cooperation is needed to seriously counter global biological threats, at least at the level of agreements between individual countries.

However, Russia itself is taking effective measures to ensure its biological security. There are two main areas of work: high-quality control over all biomaterials entering the country and technological sovereignty in such areas as the biological industry, pharmacology, food production, etc. "We were import-dependent, and quite seriously, in terms of biological media, reagents, reagents. And now we can proudly say that our industry has done the impossible – now we are completely independent of imports," Olga Kryvonos, Deputy Chief of Staff of the Government of the Russian Federation, gave an example.

The meeting participants discussed the implementation of the FNTP for the development of genetic technologies adopted in 2019, in which the Kurchatov Institute is the leading scientific organization. As Andrei Fursenko, Advisor to the President of the Russian Federation, emphasized, the program changed the very approach to domestic genetics: "We had very good, but scattered centers. They did strong work, but at the same time there was no unified logic of development. And today we have three world-class genomic research centers." Minister of Science and Education Valery Falkov noted that, in addition to the work of these large genome centres, 37 projects selected and supported by the Government are being implemented within the framework of the FNTP. Some of them are directly related to biosafety. "With a positive assessment from the head scientific organization, we will continue to pay sufficient attention to biosafety within the framework of the FNTP," the minister stressed.

The plenary session was also attended by Deputy Chairman of the State Duma Irina Yarovaya, Chairman of the Federation Council Committee on Science, Education and Culture Lilia Gumerova, Minister of Health of the Russian Federation Mikhail Murashko, Chief of the Troops of the Russian Armed Forces Igor Kirillov, Head of Rospotrebnadzor Anna Popova, Director of the Institute of Bioorganic Chemistry of the Russian Academy of Sciences Alexander Habibov.

Press Center of the National Research Center "Kurchatov Institute"

Фурсенко сообщил об изменении в России отношения к генетике

Помощник президента высоко оценил федеральный закон о создании в стране национальной базы генетической информации

nauka.tass.ru

Fursenko reported on a change in Russia's attitude to genetics

The presidential aide praised the federal law on the creation of a national database of genetic information in the country

MOSCOW, October 17, 2023.
In modern Russia, there has been a change in the attitude towards such a science as genetics. This was announced at the opening of the international conference "Kurchatov Genomic Forum" ("KurchatovGenTech-2023") at the National Research Center "Kurchatov Institute" on Tuesday by Assistant to the President of the Russian Federation Andrei Fursenko.

"Some time ago, a federal scientific and technical program for the development of genetic research was launched. <... > Key things have been done. The most important thing that has happened is that there has been a change in the general attitude towards genetics. There were very good, but disparate centers that did strong work. But at the same time, there was no single logic according to which all this developed. Today we have three world-class genomic research centers," Fursenko said.

The Federal Scientific and Technical Program for the Development of Genetic Technologies was launched in 2019 and has been extended until 2030. Its council is headed by Fursenko and Deputy Prime Minister of the Russian Federation Tatyana Golikova.*

Fursenko praised the federal law on the creation of a national database of genetic information in Russia, which comes into force on September 1, 2024. "The most important thing today is that this database is not just filled, but that everyone uses it. To begin with, it should be used by the whole of Russia, and then by our friendly countries," the presidential aide stressed.

According to the law, the functions of the customer of the national information system or database will be carried out by the Ministry of Education and Science, and its operator will be the National Research Center "Kurchatov Institute". Earlier, the President of the Russian Federation entrusted the NRC "Kurchatov Institute" with the functions of the leading scientific organization within the framework of the scientific and technical program for the development of agriculture.

According to Fursenko, it is necessary for the country to have "qualified people who could use these materials." Fursenko quoted a joke by the famous physicist, academician Boris Konstantinov, that "the 1960s were for physics what the early 1930s were for agriculture: the middle peasant went into science." Now, Fursenko added, it is necessary that "those people who will implement the achievements of science in the economy with their own hands go into science."

Biosafety priorities
Valery Falkov, Minister of Science and Higher Education of the Russian Federation, in his speech at the conference, drew attention to the issues of biological safety and three projects in this area, which were recognized as the most promising. So, first of all, it was about the Sirius University.**

"The topic of their project is the development of approaches to prevent and overcome bacterial resistance to antimicrobials. The second is the Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry: the development of means for the prevention and treatment of covid-19 and concomitant infectious diseases using genetic technologies," Falkov said.

The Minister also mentioned the Federal Center for Animal Health and its project to create a set of means of protection against animal diseases based on industrial strains of microorganisms selected by genomic sequencing methods.

"It seems to me that with a positive conclusion of the head scientific organization (the Center for World-Class Genomic Research to Ensure Biological Safety and Technological Independence - approx. TASS) we will be able to pay sufficient attention to biosafety issues within the framework of the FNTP GenTechnologies," the minister said."

***

The Federal Scientific and Technical Program for the Development of Genetic Technologies was launched in 2019 and has been extended until 2030. Its council is headed by Fursenko and Deputy Prime Minister of the Russian Federation Tatyana Golikova.*

More about Golikova:

the cornerstone: "the nature–like technosphere is a part of the noosphere.."

In two words: the common point and the sought end / intermediate goal of all the Sustainable Development Goals, green programs, digitalization, technocracy and transhumanism (of which transgenderism is a part, not the other way around) including genetic programs, mass inoculation, etc. - a peek...

vigilantcitizenforums.com

Valery Falkov, Minister of Science and Higher Education of the Russian Federation, in his speech at the conference, drew attention to the issues of biological safety and three projects in this area, which were recognized as the most promising. So, first of all, it was

about the Sirius University.**

More about Sirius University:

Russia through the hidden eye (continuation)

Neuro-V - Covid Neurorehabilitation Complex https://asi.ru/vitrina/194210/ Neurobotix has developed 7 groups of innovative medical devices for neurorehabilitation and assistive care for people with various neurological and psychosomatic diseases. The six-channel mobile neuroheadset NeuroPlay H6C...

vigilantcitizenforums.com

 

[Lalas]

KurchatovGenTech 2023: Main Topics

"КурчатовГенТех – 2023": главные темы

"КурчатовГенТех – 2023": главные темы

nrcki.ru

23.10.2023
The Kurchatov Genome Forum ("KurchatovGenTech – 2023"), the first event of the International Forum of Nature-Like Technologies, has ended at the National Research Center "Kurchatov Institute".

KurchatovGenTech 2023 was held from October 17 to 20 and brought together more than 500 participants. It opened with a large plenary session dedicated to the issues of ensuring national biological security.

In the further program of the Forum, the following events can be noted as key.

– Sections "Fundamental Genomics" and "Applied Genomics", where scientists from various scientific centers presented their achievements in the field of genetic research and spoke about their practical implementation. For the first time, these topics were considered at such a high level in a unified manner.

"The reports presented at the forum show that the level of Russian genetic research has increased qualitatively. I believe that this is the "merit" of the FNTP for the development of genetic technologies," commented Alexander Yanenko, Deputy Head of the Kurchatov Complex of NBICS Nature-Like Technologies. "We see that sequencing research has become widespread, and there is a lot of professional work related to genome editing. For example, new lines of plants and microorganisms important for agriculture have been developed."

– Round Table "National Bioresource Centers" and II Scientific and Practical Conference "Bioresource Collections: Current State and Potential for the Creation of New Technologies and Innovative Products in the Russian Federation". The attention to the topic of Russian biocollections is not accidental. Today, there are more than 100 separate collections in the country on the basis of various scientific organizations, but efforts to preserve and develop them are not always enough. As Mikhail Kovalchuk, President of the Kurchatov Institute, emphasized, today one of the main tasks is the digitization of biocollections: the decoding of the genomes of samples and their entry into the unified National Database of Genetic Information (NBGI).

The Kurchatov Institute is now actively engaged in this work. M. Kovalchuk said that a "genomic factory" has been created at the Kurchatov Institute, where sequencing (reading and decoding) of the genome is carried out with the help of high-performance modern equipment. Digitization of collections is going on around the clock. Further, the information is processed and entered into a database, where it will be possible to work with it using bioinformatics methods.

The President of the Research Center noted that the NBGI will bring Russian genetic research to a qualitatively new level:
"We have a set of biomass in the form of collections. And now a fundamentally new type of their storage is being created, which makes it possible to quickly work with genes. This is the preservation of huge biological resources and the possibility of purposefully creating new agriculture, new medicines, new medicine and diagnostic methods."

– Round table "CGIMU: Results and Plans", dedicated to the results of work and further tasks of the World-Class Genomic Research Centers, created within the framework of the Federal Scientific and Technical Program for the Development of Genetic Technologies. One of the three such centers was created on the basis of the Kurchatov Institute, its topic is genetic technologies for the development of agriculture and industrial microbiology.

- II International Youth Conference "Genetic and Radiation Technologies in Agriculture", which was held in Obninsk, at the site of the Research Center "KI" - VNIIRAE (All-Russian Research Institute of Radiology and Agroecology). The conference was attended by more than 200 scientists, including researchers from Belarus, Kazakhstan, Azerbaijan, France and Belgium.

The main topics are genomic and postgenomic technologies, genetic editing, marker-associated selection, fundamental and applied aspects of radioecology and agroecology. Also within the framework of the conference, the competition "BioSkills 2023: Science as a Way of Life" was held among schoolchildren, students and postgraduates of the Kaluga Region for prizes and grants of the Research Center "KI" – VNIIRAE.

"We regularly hold events for young scientists and see that over the past few years the level of their reports has grown a lot. In addition, their topics have changed: for example, at our last conference, there was a preponderance towards the study of plant genetics, and now the coverage of objects is wider: these are animals, fungi, and microorganisms," says Olga Shubina, Deputy Director of VNIIRAE.

Separately, O. Shubina noted the quality of school works submitted to the competition: "Some are comparable to the master's level." So, among the winners of BioSkills 2023 are schoolgirls Radmila Egorova and Polina Muryskina, who received a grant to continue their research.

Press Center of the National Research Center "Kurchatov Institute"

В Москве проходит Курчатовский форум синхротронных и нейтронных исследований

В Москве проходит Курчатовский форум синхротронных и нейтронных исследований

nrcki.ru

The Kurchatov Forum of Synchrotron and Neutron Research is taking place in Moscow

25.10.2023
The International Forum of Nature-Like Technologies, organized by the National Research Center "Kurchatov Institute", continues its work.

– On October 23, within the framework of the forum, the II meeting of the Public Council of the Basic Organization of the CIS Member States for the Development of Megascience Research Infrastructure was held.

The guest of honor of the event was the Deputy Minister of Education and Science of the Russian Federation Denis Sekirinsky. The meeting was attended by representatives of scientific centers of Russia, Belarus, Kazakhstan, Uzbekistan and Tajikistan. The specialists discussed the scientific program that will be implemented at the existing and under construction research facilities. In addition, the composition of three thematic working groups of the Base Organization was approved: on the creation and operation of the research infrastructure of the CIS countries, on the training of personnel for research on this infrastructure and on cooperation of the CIS countries in the field of genetic technologies.

The next meeting of the Public Council is scheduled for September 2024.

– On October 24, the Kurchatov Forum for Synchrotron and Neutron Research (KFSNI) opened.

More than 350 participants representing 76 scientific organizations from 18 regions of Russia, as well as from Uzbekistan and Azerbaijan registered for the forum. Two-thirds of the participants are young scientists.

Speaking at the opening of the KFSNI, Mikhail Kovalchuk, President of the National Research Center "Kurchatov Institute", stressed that Russia has all the prerequisites to be a world leader in the field of research that is carried out at megascience facilities: "Research megafacilities serve as a basis for scientific breakthroughs, because any new materials and phenomena are studied with their help. Russia remains one of the few countries that know how to invent, create, build and operate these facilities."

Press Center of the National Research Center "Kurchatov Institute"