Honorable mentions:
Descendants of Mayflower Passengers - Other source
Cousins
Politicians
Directly related
I found this website "famous kin" that connects people via distant relations. Probably not reliable but he has some interesting descendant lists like - Salem Witchcraft Trials, business founders, and others.
- Mariska Hargitay and Jayne Mansfield (satanic sacrifice) - Mother / daughter
- Jamie Lee Curtis and Janet Leigh (of Psycho fame) - Mother / daughter
- Anderson Cooper and Gloria Vanderbilt (billionaire heiress) - Mother /son - Anderson's brother Carter committed suicide at age 33 by jumping out a window in front of his mother.
- “He jumped off a balcony at my mother’s apartment building, in front of my mother, when she was begging him not to . . . Suicide is something that we don’t speak much about, and unfortunately there is still that stigma and shame surrounding [it].”
- Reese Witherspoon and John Witherspoon, who signed the United States Declaration of Independence- Source
Descendants of Mayflower Passengers - Other source
- Passenger - William Bradford
- Clint Eastwood
- Christopher Reeve
- Hugh Hefner
- George Eastman - founded KODAK camera company
- The Baldwins
- Passenger - William Brewster
- Bing Crosby
- Katherine Hepburn
- Richard Gere
- Ashley Judd
- Jordana Brewster
- Elizabeth Shue
- Passenger - John Howland
- George Bush & Jr
- Franklin Roosevelt
- Humphrey Bogart
Cousins
Politicians
- Barack Obama and Cheney, Bush, Churchill, Ford, Johnson, Truman, Madison, Brad Pitt - Source - same for Clinton
- Hillary Clinton and Angelina Jolie, Madonna, Celine Dion, Alanis Morissette, Jack Kerouac, and Camilla Parker-Bowles - Source
- Tom Hanks and Abraham Lincoln - Source
- Democratic Sen. Cory Booker from New Jersey and RuPaul
- Richard Nixon & Kyra Sedgwick
- Sarah Palin & Halle Berry
- Chuck & Amy Schumer
- Denis Leary and Conan O'Brien
- Justin Bieber and Ryan Gosling
- Nicolas Cage, Sofia Coppola, and Jason Schwartzman
- Rip Torn and Sissy Spacek
- Snoop Dogg and Brandy and Ray J
- Melissa McCarthy and Jenny McCarthy
- Jeff Bezos and George Strait - Source
- Fantasia Barrino & K-Ci & Jojo
Directly related
- Jason Sudeikis and George Wendt - Uncle / nephew
- Quincy Jones and Rashida Jones - Father / daughter
- Elle King and Rob Schneider - Father / daughter
- Lea Thompson and Zoey Deutch - Mother / daughter
- Melanie Griffith and Dakota Johnson - Mother / daughter
- Julia Roberts and Emma Roberts - Aunt / niece
- Francis Ford Coppola and Nicholas Cage - Uncle / nephew
- Jessica Capshaw and Steven Spielberg - He is her stepfather.
- Christian Bale and Gloria Steinem - She is his stepmother.
- Jake Gyllenhaal and Peter Sarsgaard - Brothers-in-law.
- Nicole Richie and Cameron Diaz - Sisters in law
- Emily Blunt and Stanley Tucci - In-laws.
- Jason Momoa and Zoë Kravitz - He is her stepfather. Al Roker is also Lenny Kravitz cousin.
- Barbra Streisand and Josh Brolin - She is his stepmother.
- Dateline host Keith Morrison and Matthew Perry - Keith is Matthew's stepfather
- Kate Spade and David Spade - She was his sister in law
- Reba McEntire and Kelly Clarkson -Mother -in law
I found this website "famous kin" that connects people via distant relations. Probably not reliable but he has some interesting descendant lists like - Salem Witchcraft Trials, business founders, and others.